ehyl 2-[N-ethoxyformyl methyl-N-(4-formylphenyl)]amino acetate

Base Information

• Chemical Name: ehyl 2-[N-ethoxyformyl methyl-N-(4-formylphenyl)]amino acetate
• CAS No.: 27919-79-5
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.32
• Mol file: 27919-79-5.mol

Synonyms:ehyl 2-[N-ethoxyformyl methyl-N-(4-formylphenyl)]amino acetate

Chemical Property of ehyl 2-[N-ethoxyformyl methyl-N-(4-formylphenyl)]amino acetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Diethyl 2,2-[(4-formylphenyl)imino]diacetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ehyl 2-[N-ethoxyformyl methyl-N-(4-formylphenyl)]amino acetate

There total 5 articles about ehyl 2-[N-ethoxyformyl methyl-N-(4-formylphenyl)]amino acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

phenyliminodiacetic acid diethyl ester (55932-12-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → ehyl 2-[N-ethoxyformyl methyl-N-(4-formylphenyl)]amino acetate (27919-79-5)

Guidance literature:

With trichlorophosphate; at 20 - 90 ℃; for 2.5h;

DOI:10.1021/jo201290a

Reference yield:

4-aminobenzaldehyde (556-18-3,28107-09-7) + chloroacetic acid ethyl ester (105-39-5) → ehyl 2-[N-ethoxyformyl methyl-N-(4-formylphenyl)]amino acetate (27919-79-5)

Guidance literature:

4-aminobenzaldehyde; chloroacetic acid ethyl ester; In ethanol; for 0.5h; Cooling with ice;

With caesium carbonate; at 20 ℃; for 5h;

Reference yield:

aniline (62-53-3) → ehyl 2-[N-ethoxyformyl methyl-N-(4-formylphenyl)]amino acetate (27919-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: trichlorophosphate / 2.5 h / 20 - 90 °C

With pyridine; trichlorophosphate; In dichloromethane;

DOI:10.1021/jo201290a

upstream raw materials:

phenyliminodiacetic acid diethyl ester

N,N-dimethyl-formamide

aniline

4-aminobenzaldehyde

Downstream raw materials:

C₂₉H₂₅N₃O₆

C₂₉H₂₇N₅O₆

Refernces

• 1、 Wang, Jiaobing,Qian, Xuhong. "A series of polyamide receptor based PET fluorescent sensor molecules: Positively cooperative Hg2+ ion binding with high sensitivity". . p. 3721 - 3724. Retrieved 2006.
• 2、 Zhao, Bing,Fang, Yue,Ma, Ming-Jie,Deng, Qi-Gang,Xu, Yu,Wang, Li-Yan. "A new on-fluorescent sensor for Ag+ based on benzimidazole bearing bis(ethoxycarbonylmethyl)amino groups". . p. 211 - 214. Retrieved 2015.
• 3、 -. "Polydentate ligand terpyridyl diacetate and preparation method thereof". Paragraph 0042-0044. . Retrieved 2019/04/30.
• 4、 -. "Fluorescent probe for detecting content of metal ions in water and application of fluorescent probe". Paragraph 0016; 0035. . Retrieved 2019/12/02.