1-(3,4,5-Trimethoxy-benzyl)-piperazine dihydrochloride

Base Information

• Chemical Name: 1-(3,4,5-Trimethoxy-benzyl)-piperazine dihydrochloride
• CAS No.: 107049-57-0
• Molecular Formula: C14H22 N2 O3 . 2 Cl H
• Molecular Weight: 339.25796
• European Community (EC) Number: 642-164-1
• Mol file: 107049-57-0.mol

Synonyms:1-(3,4,5-trimethoxy-benzyl)-piperazine dihydrochloride;107049-57-0;1-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride;1-[(3,4,5-trimethoxyphenyl)methyl]piperazine;dihydrochloride;Trimetazidine Dihydrochloride Imp. A (EP);Trimetazidine Imp. A (EP);1-(3,4,5-Trimethoxybenzyl)piperazine Dihydrochloride;Trimetazidine Dihydrochloride Imp. A (EP) as Dihydrochloride;Trimetazidine Dihydrochloride Impurity A as Dihydrochloride;Trimetazidine Impurity A as Dihydrochloride;SCHEMBL4811662;XIRALXKCBGTYSC-UHFFFAOYSA-N;AKOS015845357;1(3,4,5-trimethoxybenzyl)piperazine dihydrochloride;1-(3,4,5trimethoxybenzyl)piperazine dihydrochloride;1-(3,4,5-Trimethoxy-benzyl)-piperazinedihydrochloride;1-(3,4,5-trimethyoxybenzyl)piperazine dihydrochloride;N1-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride;Trimetazidine Dihydrochloride Imp. A (EP) as Dihydrochloride: 1-(3,4,5-Trimethoxybenzyl)piperazine Dihydrochloride

Chemical Property of 1-(3,4,5-Trimethoxy-benzyl)-piperazine dihydrochloride

Chemical Property:

• PSA: 42.96000
• LogP: 2.18630
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 338.1163980
• Heavy Atom Count: 21
• Complexity: 245

Purity/Quality:

99.90% ^*data from raw suppliers

1-(3,4,5-TRIMETHOXY-BENZYL)-PIPERAZINE DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)OC)CN2CCNCC2.Cl.Cl

Technology Process of 1-(3,4,5-Trimethoxy-benzyl)-piperazine dihydrochloride

There total 2 articles about 1-(3,4,5-Trimethoxy-benzyl)-piperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

piperazine (110-85-0) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → 1-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride (107049-57-0)

Guidance literature:

With sodium hydroxide; In formic acid; 1.) 100 deg C, 5 h; 2.) reflux, 2 h;

DOI:10.1248/cpb.35.2782

Reference yield:

piperazine (110-85-0) + 5-(chloromethyl)-1,2,3-trimethoxybenzene (3840-30-0) → 1-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride (107049-57-0)

Guidance literature:

In ethanol; at 60 ℃; for 2h;

DOI:10.1248/cpb.35.2782

Reference yield:

hydrogen chloride - ethyl acetate + pyridine-3-carbonyl chloride hydrochloride (20260-53-1) + 1-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride (107049-57-0) → 1-(nicotinoyl)-4-(3,4,5-trimethoxybenzoyl)piperazine dihydrochloride

Guidance literature:

With sodium hydrogencarbonate; potassium carbonate; In ethanol; water; ethyl acetate;

upstream raw materials:

piperazine

3,4,5-trimethoxy-benzaldehyde

5-(chloromethyl)-1,2,3-trimethoxybenzene

Downstream raw materials:

5,6-Dimethoxy-2-[4-(3,4,5-trimethoxy-benzyl)-piperazin-1-ylmethyl]-3,4-dihydro-2H-naphthalen-1-one; hydrochloride

1-(2,4-dichlorobenzoylethyl)-4-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride

1-[(4-methoxyphenoxy)carbonylmethyl]-4-(3,4,5-trimethoxybenzyl)piperazine

1-(3,4-dichlorobenzoylethyl)-4-(3,4,5-trimethoxybenzyl)piperazine dihydrochloride

Refernces