2-Phenylbenzenesulfonyl chloride

Base Information

• Chemical Name: 2-Phenylbenzenesulfonyl chloride
• CAS No.: 2688-90-6
• Molecular Formula: C12H9ClO2S
• Molecular Weight: 252.721
• Hs Code.: 2904909090
• European Community (EC) Number: 638-911-6
• DSSTox Substance ID: DTXSID20373485
• Wikidata: Q82161675
• Mol file: 2688-90-6.mol

Synonyms:2688-90-6;Biphenyl-2-sulfonyl chloride;2-Phenylbenzenesulfonyl chloride;[1,1'-Biphenyl]-2-sulfonyl chloride;1,1'-biphenyl-2-sulfonyl chloride;2-phenylbenzenesulphonyl chloride;[1,1'-Biphenyl]-2-sulfonylchloride;biphenylsulfonylchloride;Biphenylmonosulfochlorid;2-biphenylsulfonyl chloride;2-biphenylsulphonyl chloride;2-bi-phenylsulfonyl chloride;SCHEMBL313390;2-Phenylphenylsulfonyl chloride;DTXSID20373485;RENKNADFNRIRNZ-UHFFFAOYSA-N;2-phenylbenzene-1-sulfonyl chloride;AR1235;MFCD02246591;AKOS000126079;biphenyl-2-sulfonyl chloride, AldrichCPR;AS-45063;CS-0205889;EN300-29809;A924966;J-016585;Z235353825

Chemical Property of 2-Phenylbenzenesulfonyl chloride

Chemical Property:

• Vapor Pressure: 5.48E-06mmHg at 25°C
• Refractive Index: 1.595
• Boiling Point: 391.6 °C at 760 mmHg
• Flash Point: 190.7 °C
• PSA: 42.52000
• Density: 1.32 g/cm³
• LogP: 4.36190
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 252.0011784
• Heavy Atom Count: 16
• Complexity: 314

Purity/Quality:

98%min ^*data from raw suppliers

Biphenyl-2-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=CC=C2S(=O)(=O)Cl

Technology Process of 2-Phenylbenzenesulfonyl chloride

There total 7 articles about 2-Phenylbenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-Bromobiphenyl (2052-07-5) → 2-phenylbenzenesulfonyl chloride (2688-90-6)

Guidance literature:

With n-butyllithium; sulfuryl dichloride; sulfur dioxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;

Reference yield: 51.0%

2-Bromobiphenyl (2052-07-5) → 2-phenylbenzenesulfonyl chloride (2688-90-6)

Guidance literature:

With n-butyllithium; sulfuryl dichloride; In hexane; ethyl acetate;

Reference yield: 51.0%

n-butyllithium (109-72-8,29786-93-4) + 2-Bromobiphenyl (2052-07-5) → 2-phenylbenzenesulfonyl chloride (2688-90-6)

Guidance literature:

With sulfuryl dichloride; In hexane; ethyl acetate;

upstream raw materials:

2-iodobiphenyl

2-phenylaniline

2-Bromobiphenyl

n-butyllithium

Downstream raw materials:

dibenzothiophene sulfone

methyl 2-((4-([1,1′-biphenyl]-2-ylsulfonamido)-1-methoxynaphthalen-2-yl)thio)acetate

C₃₃H₃₄FN₃O₃S

(2RS)-[1-(biphenyl-2-sulfonyl)azetidin-2-ylmethyl]carbamic acid tert-butyl ester

Refernces

• 1、 -. "N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin". Page column 143. . Retrieved 2010/01/30.
• 2、 -. "Sulfonamide substituted aspartic acid interleukin-1 beta converting enzyme inhibitors". . . Retrieved 2008/06/13.