Ranitidine HCl

Base Information

• Chemical Name: Ranitidine HCl
• CAS No.: 70956-04-6
• Molecular Formula: C13H23ClN4O3S
• Molecular Weight: 0
• Mol file: 70956-04-6.mol

Synonyms:

Chemical Property of Ranitidine HCl

Chemical Property:

• PSA: 111.56000
• LogP: 3.56600

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of Ranitidine HCl

There total 34 articles about Ranitidine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(E-)-N-methyl-1-(methylthio)-2-nitroethanamine (61832-41-5) + 5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine (66356-53-4) → Ranitidine (66357-35-5,70956-04-6)

Guidance literature:

In water; at 55 ℃;

DOI:10.1002/anie.201602883

Reference yield: 90.0%

1,1-dichloro-2-nitro ethylene (6061-04-7) + 2-mercaptoethylamine hydrochloride (156-57-0) + 5-(N,N'-dimethylaminomethyl)-2-chloromethyl-furan + methylamine (74-89-5) → Ranitidine (66357-35-5,70956-04-6)

Guidance literature:

1,1-dichloro-2-nitro ethylene; 2-mercaptoethylamine hydrochloride; With sodium hydroxide; at 50 ℃; for 1h;

methylamine; With calcium oxide; In ethanol; at 20 ℃; for 12h;

5-(N,N'-dimethylaminomethyl)-2-chloromethyl-furan; In ethanol; water; at 45 ℃; for 2h; Temperature;

Reference yield: 17.3%

(Z)-1-β-hydroxyethylamino-1-methylamino-2-nitroethene + 5-(N,N-dimethylaminomethyl)-2-thiomethylfuran hydrobromide → Ranitidine (66357-35-5,70956-04-6)

Guidance literature:

(Z)-1-β-hydroxyethylamino-1-methylamino-2-nitroethene; 5-(N,N-dimethylaminomethyl)-2-thiomethylfuran hydrobromide; With hydrogenchloride; at 0 ℃; for 40h;

With sodium hydroxide; sodium chloride; at 0 ℃; pH=9;

upstream raw materials:

nitromethane

N-methyl-N'-(2-<(5-dimethylaminomethyl)-furan-2-ylmethylthio>-ethyl)-carbodiimide

N,N-dimethylammonium chloride

N-methyl-N'-(2-<(5-dimethylaminomethyl)-furan-2-ylmethylthio>-ethyl)-urea

Downstream raw materials:

Ranitidine S-oxide

Refernces

• 1、 -. "Ranitidine oral preparation for treating new indications of erosive esophagitis". Paragraph 0240; 0241; 0242; 0243; 0244-0247; 0274; 0287. . Retrieved 2018/11/22.
• 2、 Galkin, Konstantin I.,Krivodaeva, Elena A.,Romashov, Leonid V.,Zalesskiy, Sergey S.,Kachala, Vadim V.,Burykina, Julia V.,Ananikov, Valentine P.. "Critical Influence of 5-Hydroxymethylfurfural Aging and Decomposition on the Utility of Biomass Conversion in Organic Synthesis". supporting information. p. 8338 - 8342. Retrieved 2016/07/19.