methyl 2-(benzyloxycarbonylamino)-2-methoxyacetate

Base Information

• Chemical Name: methyl 2-(benzyloxycarbonylamino)-2-methoxyacetate
• CAS No.: 127357-37-3
• Molecular Formula: C₁₂H₁₅NO₅
• Molecular Weight: 253.255
• Mol file: 127357-37-3.mol

Synonyms:methyl 2-(benzyloxycarbonylamino)-2-methoxyacetate

Chemical Property of methyl 2-(benzyloxycarbonylamino)-2-methoxyacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(benzyloxycarbonylamino)-2-methoxyacetate

There total 10 articles about methyl 2-(benzyloxycarbonylamino)-2-methoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + N-benzyloxycarbonyl-glycine (79002-45-2,56538-57-9) → methyl 2-(benzyloxycarbonylamino)-2-methoxyacetate (127357-37-3,58237-86-8)

Guidance literature:

With sulfuric acid; for 48h;

DOI:10.1016/S0040-4039(00)60554-3

Reference yield: 96.0%

methanol (67-56-1) + N-carbobenzoxy-N-chloroglycine methyl ester (129778-98-9) → methyl 2-(benzyloxycarbonylamino)-2-methoxyacetate (127357-37-3,58237-86-8)

Guidance literature:

With sodium methylate; at -78 ℃; for 6h;

DOI:10.1080/00397919608003521

Reference yield: 92.0%

methanol (67-56-1) + O-benzyl carbamate (621-84-1) → methyl 2-(benzyloxycarbonylamino)-2-methoxyacetate (127357-37-3,58237-86-8)

Guidance literature:

With sulfuric acid;

upstream raw materials:

methanol

N-benzyloxycarbonyl-glycine

N-carbobenzoxy-N-chloroglycine methyl ester

O-benzyl carbamate

Downstream raw materials:

2-Benzyloxycarbonylamino-4,4-diphenyl-but-3-enoic acid

2-Benzyloxycarbonylamino-4,4-diphenyl-but-3-enoic acid methyl ester

Benzyloxycarbonylamino-p-tolylselanyl-acetic acid methyl ester

Benzyloxycarbonylamino-phenylselanyl-acetic acid methyl ester

Refernces

• 1、 -. "Preparation method of Wittig-Horner reagent". Paragraph 0030-0032; 0035-0037. . Retrieved 2021/07/31.
• 2、 Reutzel, Jan,Diogo, Timm M.,Geyer, Armin. "Reversible Folding of a β-Hairpin Peptide by a Metal-Chelating Amino Acid". supporting information. p. 8450 - 8456. Retrieved 2017/06/28.