2-Bromo-2-methylbutanoyl bromide

Base Information

• Chemical Name: 2-Bromo-2-methylbutanoyl bromide
• CAS No.: 106265-07-0
• Molecular Formula: C5H8Br2O
• Molecular Weight: 243.92
• Hs Code.: 2915900090
• Mol file: 106265-07-0.mol

Synonyms:2-Bromo-2-Methylbutanoyl Bromide

Chemical Property of 2-Bromo-2-methylbutanoyl bromide

Chemical Property:

• Vapor Pressure: 0.548mmHg at 25°C
• Refractive Index: 1.516
• Boiling Point: 190.2 °C at 760 mmHg
• Flash Point: 61.5 °C
• PSA: 17.07000
• Density: 1.812 g/cm³
• LogP: 2.47150

Purity/Quality:

98%Min ^*data from raw suppliers

2-Bromo-2-methylbutanoylbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-2-methylbutanoyl bromide

There total 2 articles about 2-Bromo-2-methylbutanoyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methylbutanoic acid (116-53-0,600-07-7) → (2R,S)-2-Bromo-2-methylbutanoyl bromide (106265-07-0)

Guidance literature:

2-Methylbutanoic acid; With phosphorus tribromide; at 20 ℃; Inert atmosphere; Sealed tube;

With bromine; at 110 ℃; for 6h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tet.2019.03.048

Reference yield:

3-methylbutyric acid (503-74-2) → (2R,S)-2-Bromo-2-methylbutanoyl bromide (106265-07-0)

Guidance literature:

With phosphorus; bromine;

DOI:10.1039/jr9340001070

Reference yield: 92.0%

(2R,S)-2-Bromo-2-methylbutanoyl bromide (106265-07-0) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → (2R,S)-L-2-Bromo-2-(methylbutanoyl)phenylalanine methyl ester (169058-15-5)

Guidance literature:

With triethylamine; In chloroform; for 14h; Ambient temperature;

DOI:10.1021/jo00118a017

upstream raw materials:

3-methylbutyric acid

2-Methylbutanoic acid

Downstream raw materials:

(2R,S)-L-2-Bromo-2-(methylbutanoyl)phenylalanine methyl ester

(2-Methyl-trans-crotonoyl)-harnstoff

Refernces

• 1、 Wei, Kaijie,Liang, Siyu,Yang, Tonghao,Yu, Wei. "Iron-Catalyzed 1,4-Phenyl Migration/Ring Expansion of α-Azido N-Phenyl Amides". supporting information. p. 8650 - 8654. Retrieved 2021/11/13.