Trifluoromethoxybenzaldehyde2

Base Information

• Chemical Name: Trifluoromethoxybenzaldehyde2
• CAS No.: 50823-91-1
• Molecular Formula: C₈H₅F₃O₂
• Molecular Weight: 190.122
• Mol file: 50823-91-1.mol

Synonyms:3-Trifluoromethoxybenzaldehyde;

Chemical Property of Trifluoromethoxybenzaldehyde2

Chemical Property:

• Vapor Pressure: 0.648mmHg at 25°C
• Refractive Index: 1.454
• Boiling Point: 186.9°Cat760mmHg
• Flash Point: 73 ºC
• PSA: 26.30000
• Density: 1.33
• LogP: 2.39770

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(TRIFLUOROMETHOXY)BENZALDEHYDE 97 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Trifluoromethoxybenzaldehyde2

There total 9 articles about Trifluoromethoxybenzaldehyde2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-bromo-3-(trifluoromethoxy)benzene (2252-44-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-(trifluoromethoxy)benzaldehyde (52771-21-8,50823-91-1)

Guidance literature:

1-bromo-3-(trifluoromethoxy)benzene; With n-butyllithium; In diethyl ether; hexane; at -75 ℃; for 0.75h;

N,N-dimethyl-formamide; In diethyl ether; hexane; at -75 ℃; Further stages.;

DOI:10.1002/1099-0690(200102)2001:4<691::AID-EJOC691>3.0.CO;2-A

Reference yield: 44.0%

sodium hydrogensulfite + 1-cyano-3-trifluoromethoxybenzene (52771-22-9) → 3-(trifluoromethoxy)benzaldehyde (52771-21-8,50823-91-1)

Guidance literature:

With stannous chloride; potassium carbonate; In diethyl ether; water;

Reference yield:

3-methyl-4-nitro-1-(trifluoromethoxy)-6-(trifluoromethyl)-1H-benzo[d][1,2,3]triazol-3-ium trifluoromethanesulfonate + benzaldehyde (100-52-7) → p-trifluoromethoxybenzaldehyde (659-28-9) + 2-(trifluoromethoxy)benzaldehyde (94651-33-9) + 3-(trifluoromethoxy)benzaldehyde (52771-21-8,50823-91-1)

Guidance literature:

With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; In acetonitrile; at 20 ℃; for 1h; Overall yield = 57 percentSpectr.; Inert atmosphere; Flow reactor; Irradiation;

DOI:10.3762/bjoc.16.111

upstream raw materials:

[3-(trifluoromethoxy)phenyl]methanol

1-bromo-3-(trifluoromethoxy)benzene

N,N-dimethyl-formamide

3-Trichlormethoxy-benzoesaeure-chlorid

Downstream raw materials:

[acetylamino-(3-trifluoromethoxy-phenyl)-methyl]-phosphonic acid

Refernces

• 1、 Cendón, Borja,Gulías, Moisés,Ho, Michelle,No?l, Timothy,Nyuchev, Alexander V.,Sambiagio, Carlo,Struijs, Job J. C.,Wan, Ting,Wang, Ying. "Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow". supporting information. p. 1305 - 1312. Retrieved 2020/07/10.
• 2、 -. "Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof". . . Retrieved 2008/06/13.