2-BROMO-3-FLUORO-6-PICOLINE

Base Information

• Chemical Name: 2-BROMO-3-FLUORO-6-PICOLINE
• CAS No.: 374633-36-0
• Molecular Formula: C6H5BrFN
• Molecular Weight: 190.015
• Hs Code.: 2933399090
• Mol file: 374633-36-0.mol

Synonyms:2-Bromo-3-fluoro-6-methylpyridine;2-Bromo-3-fluoro-6-picoline;2-BROMO-3-FLUORO-6-PICOLINE;

Chemical Property of 2-BROMO-3-FLUORO-6-PICOLINE

Chemical Property:

• Vapor Pressure: 0.949mmHg at 25°C
• Refractive Index: 1.529
• Boiling Point: 185.6 °C at 760 mmHg
• PKA: -0.91±0.10(Predicted)
• Flash Point: 66 °C
• PSA: 12.89000
• Density: 1.592 g/cm³
• LogP: 2.29160
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-3-fluoro-6-picoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 2-Bromo-3-fluoro-6-picoline is a chemical compound with several applications across different fields. In the pharmaceutical industry, it serves as a valuable intermediate in the synthesis of various pharmaceutical compounds. Its role in this context is crucial for the development of drugs with potential therapeutic benefits, making it an essential building block in drug discovery and synthesis. Additionally, in the field of agrochemicals, it can be used in the formulation of herbicides and pesticides, contributing to crop protection and improved agricultural yields. Furthermore, in research and development, this compound may serve as a starting material for exploring new chemical reactions and applications in various scientific studies. Its versatility and importance in pharmaceuticals and agriculture highlight its significance in advancing these industries and the broader scientific community.

Technology Process of 2-BROMO-3-FLUORO-6-PICOLINE

There total 1 articles about 2-BROMO-3-FLUORO-6-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

3-amino-2-bromo-6-methylpyridine (126325-53-9) → 2-bromo-3-fluoro-6-methylpyridine (374633-36-0)

Guidance literature:

3-amino-2-bromo-6-methylpyridine; With hydrogenchloride; sodium nitrite; In water; at -5 - 0 ℃;

With hexafluorophosphoric acid; In water; Cooling;

at 100 ℃; for 0.166667h;

DOI:10.1016/j.bmcl.2015.09.058

Reference yield: 100.0%

2-bromo-3-fluoro-6-methylpyridine (374633-36-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-fluoro-6-methyl-2-pyridinecarboxaldehyde (884495-48-1)

Guidance literature:

2-bromo-3-fluoro-6-methylpyridine; With TurboGrignard; In tetrahydrofuran; at 0 ℃; for 5h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -42 ℃; for 2h;

Reference yield: 98.0%

2-bromo-3-fluoro-6-methylpyridine (374633-36-0) + copper(II) cyanide → 3-(4-fluorophenyl)-6-methylpyridine-2-carbonitrile

Guidance literature:

In N,N-dimethyl-formamide; at 110 ℃;

upstream raw materials:

3-amino-2-bromo-6-methylpyridine

Downstream raw materials:

tert-butyl 3-[(3-fluoro-6-methylpyridin-2-yl)amino]-6,6-dimethyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate

6-bromo-5-fluoro-pyridine-2-carboxylic acid

2-(2',6'-difluorophenyl)-3-fluoro-6-methylpyridine

3-fluoro-6-methyl-2-(2,3,5-trifluorophenyl)pyridine

Refernces