2-Amidinothiophene hydrochloride

Base Information

• Chemical Name: 2-Amidinothiophene hydrochloride
• CAS No.: 54610-70-7
• Molecular Formula: C5H6 N2 S . Cl H
• Molecular Weight: 162.643
• Hs Code.: 2934999090
• European Community (EC) Number: 672-844-3
• DSSTox Substance ID: DTXSID90381850
• Mol file: 54610-70-7.mol

Synonyms:54610-70-7;2-Amidinothiophene hydrochloride;Thiophene-2-carboximidamide Hydrochloride;thiophene-2-carboxamidine hydrochloride;2-Amidinothiophene, HCl;thiophene-2-carboximidamide;hydrochloride;Thiophene-2-carboximidamide HCl;thiophene-2-amidine hydrochloride;2-Thiophenecarboxamidine HCl;2-AMIDINOTHIOPHENEHYDROCHLORIDE;thiophene-2-carboximidamide,hydrochloride;2-Thiophenecarboximidamide, monohydrochloride;thiophene-2-carboxamidine hcl;2-AMIDINOTHIOPHENE HCL;SCHEMBL497550;2-thienylformamidine hydrochloride;DTXSID90381850;URAGJMBGNVOIJC-UHFFFAOYSA-N;AMY24706;MFCD00173786;AKOS008090185;CS-10918;A7926;FT-0640264;EN300-37008;5L-0512;Thiophene-2-carboximidamide hydrochloride, AldrichCPR;F8889-9263;Z381357622

Chemical Property of 2-Amidinothiophene hydrochloride

Chemical Property:

• Vapor Pressure: 0.111mmHg at 25°C
• Melting Point: 172-175°C
• Boiling Point: 220.8°C at 760 mmHg
• Flash Point: 87.3°C
• PSA: 78.11000
• LogP: 2.63420
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 162.0018471
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

99% ^*data from raw suppliers

Thiophene-2-carboximidamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)C(=N)N.Cl

Technology Process of 2-Amidinothiophene hydrochloride

There total 5 articles about 2-Amidinothiophene hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ thiophene-2-carboximidamide hydrochloride (54610-70-7)

Guidance literature:

Reference yield: 75.0%

N'-hydroxythiophene-2-carboximidamide (53370-51-7) → thiophene-2-carboximidamide hydrochloride (54610-70-7)

Guidance literature:

N'-hydroxythiophene-2-carboximidamide; With acetic anhydride; acetic acid; at 20 ℃; for 0.5h;

With triethylsilane; palladium dichloride; at 70 - 75 ℃; for 2.5h;

With hydrogenchloride; In ethanol;

DOI:10.1080/00397911.2010.488307

Reference yield: 48.5%

thiophene-2-carbonitrile (1003-31-2) → thiophene-2-carboximidamide hydrochloride (54610-70-7)

Guidance literature:

thiophene-2-carbonitrile; With sodium methylate; In methanol; at 0 - 20 ℃; for 3h; Inert atmosphere;

With ammonium chloride; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2015.12.013

upstream raw materials:

methyl thiophene-2-carbimidate hydrochloride

thiophene-2-carbonitrile

N'-hydroxythiophene-2-carboximidamide

Downstream raw materials:

5-(2-amino-5-chlorophenyl)-3-(2-thienyl)-1H-1,2,4-triazole

4-(2-Azido-ethyl)-5-(4-methoxy-phenyl)-2-thiophen-2-yl-1H-imidazole

5-diethoxymethyl-2-thiophen-2-ylpyrimidine

Ethyl 5-amino-4-(3-methoxyphenyl)-2-(2-thienyl)-thieno[2,3-d]pyrimidine-6-carboxylate

Refernces

• 1、 Dong, Jianghong,Chen, Shengwei,Li, Runfeng,Cui, Wei,Jiang, Haiming,Ling, Yixia,Yang, Zifeng,Hu, Wenhui. "Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus". . p. 605 - 615. Retrieved 2015/12/30.
• 2、 Mahajan, Umesh S.,Godinde, Rupesh R.,Mandhare. "Preparation of amidines from amidoximes via transfer hydrogenation". experimental part. p. 2195 - 2199. Retrieved 2011/06/27.