1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE

Base Information

• Chemical Name: 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE
• CAS No.: 406482-22-2
• Molecular Formula: C7H5BrF2O
• Molecular Weight: 223.017
• Hs Code.: 2909309090
• Mol file: 406482-22-2.mol

Synonyms:1-Bromo-2,3-difluoro-4-methoxybenzene;4-Bromo-2,3-difluoroanisole;

Chemical Property of 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE

Chemical Property:

• Appearance/Colour: pale yellow liquid
• Vapor Pressure: 0.4mmHg at 25°C
• Refractive Index: 1.5
• Boiling Point: 203.2 °C at 760 mmHg
• Flash Point: 91.1 °C
• PSA: 9.23000
• Density: 1.615 g/cm³
• LogP: 2.73590
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-2,3-difluoroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE

There total 3 articles about 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,3-difluoro-4-bromophenol (144292-32-0) + methyl iodide (74-88-4) → 1-bromo-2,3-difluoro-4-methoxybenzene (406482-22-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 72h;

Reference yield: 81.0%

2,3-difluoro-4-bromophenol (144292-32-0) + dimethyl sulfate (77-78-1) → 1-bromo-2,3-difluoro-4-methoxybenzene (406482-22-2)

Guidance literature:

With potassium hydroxide; In water;

DOI:10.1055/s-0030-1260551

Reference yield:

2.3-difluoroanisole (134364-69-5) → 1-bromo-2,3-difluoro-4-methoxybenzene (406482-22-2)

Guidance literature:

With bromine; triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.33333h;

upstream raw materials:

2.3-difluoroanisole

2,3-difluoro-4-bromophenol

dimethyl sulfate

methyl iodide

Downstream raw materials:

2-bromo-3-(2,3-difluoro-4-methoxy-phenyl)-4,5,6,6a-tetrahydro-3aH-pentalen-1-one

(2,3-difluoro-4-methoxyphenyl)boronic acid

3-(2-bromo-4-fluorophenoxy)-2',3'-difluoro-4'-methoxybiphenyl-2-carbonitrile

3-(2-bromo-5-(trifluoromethoxy)phenoxy)-2',3'-difluoro-4'-methoxybiphenyl-2-carbonitrile

Refernces

• 1、 Hopf, Henning,Hussain, Zakir,Menon, Rajeev S.,Raev, Vitaly,Jones, Peter G.,Pohl, Ludwig M.. "Perhydroazulenes - A new class of liquid crystalline materials". scheme or table. p. 1273 - 1276. Retrieved 2011/07/06.