4-Ethylphenylhydrazine hydrochloride

Base Information

• Chemical Name: 4-Ethylphenylhydrazine hydrochloride
• CAS No.: 53661-18-0
• Molecular Formula: C8H12N2^.HCl
• Molecular Weight: 172.658
• Hs Code.: 29280000
• European Community (EC) Number: 674-306-3
• DSSTox Substance ID: DTXSID60375448
• Mol file: 53661-18-0.mol

Synonyms:53661-18-0;4-Ethylphenylhydrazine hydrochloride;(4-ethylphenyl)hydrazine Hydrochloride;4-ethylphenylhydrazine hcl;4-Ethylphenylhydrazine, HCl;(4-ethyl-phenyl)-hydrazine hydrochloride;1-(4-ethylphenyl)hydrazine hydrochloride;4-Ethylphenylhydrazinehydrochloride;(4-ethylphenyl)hydrazine;hydrochloride;Hydrazine, (4-ethylphenyl)-, monohydrochloride;MFCD01861267;(4-ETHYLPHENYL)HYDRAZINE HCL;SCHEMBL1160367;DTXSID60375448;YGFUKCJADFMHGW-UHFFFAOYSA-N;4-ethyl phenyl hydrazine hydrochloride;AKOS001476449;CS-W002839;GS-3513;SY014211;A7806;FT-0650500;EN300-246649;1-(4-ethylphenyl)hydrazine hydrochloric acid salt;J-501401;(4-Ethyl-phenyl)-hydrazine hydrochloride, AldrichCPR

Chemical Property of 4-Ethylphenylhydrazine hydrochloride

Chemical Property:

• Vapor Pressure: 0.0144mmHg at 25°C
• Melting Point: 67-71 °C
• Boiling Point: 257.6 °C at 760 mmHg
• Flash Point: 126.2 °C
• PSA: 38.05000
• LogP: 3.10990
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 172.0767261
• Heavy Atom Count: 11
• Complexity: 85.3

Purity/Quality:

99% ^*data from raw suppliers

4-Ethylphenylhydrazine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC=C(C=C1)NN.Cl
• Uses: 4-Ethylphenylhydrazine, HCl

Technology Process of 4-Ethylphenylhydrazine hydrochloride

There total 3 articles about 4-Ethylphenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-aminoethylbenzene (589-16-2) → p-ethylphenylhydrazine hydrochloride (53661-18-0)

Guidance literature:

4-aminoethylbenzene; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With hydrogenchloride; tin(ll) chloride; In water; at -10 ℃; for 1.5h;

Reference yield: 72.0%

4-ethyl-1-iodobenzene (25309-64-2) → p-ethylphenylhydrazine hydrochloride (53661-18-0)

Guidance literature:

4-ethyl-1-iodobenzene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 55.0%

1-bromo-4-ethylbenzene (1585-07-5) → p-ethylphenylhydrazine hydrochloride (53661-18-0)

Guidance literature:

1-bromo-4-ethylbenzene; With potassium phosphate; N,N'-bis(2,5-dimethylpyrrol-1-yl)oxalamide; cetyltrimethylammonim bromide; copper(I) bromide; In water; at 80 ℃; for 0.166667h; Sealed tube; Inert atmosphere;

With hydrazine hydrate; In water; at 80 ℃; for 2h; Sealed tube; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water;

DOI:10.1016/j.tet.2014.04.048

upstream raw materials:

4-aminoethylbenzene

1-bromo-4-ethylbenzene

4-ethyl-1-iodobenzene

Downstream raw materials:

N-(4-Ethyl-phenyl)-N'-[1-phenyl-1-(5-phenyl-[1,2,4]oxadiazol-3-yl)-meth-(Z)-ylidene]-hydrazine

N-(4-Ethyl-phenyl)-N'-[1-phenyl-1-(5-phenyl-[1,2,4]oxadiazol-3-yl)-meth-(E)-ylidene]-hydrazine

4-ethylbenzenesulfonyl fluoride

Refernces

• 1、 Jin, Xiao-Yan,Zhang, Kang-Ping,Chen, Hao,Miao, Ting-Ting,Wang, Shi-Fa,Gu, Wen. "Synthesis, in vitro Antimicrobial, and Cytotoxic Activities of New 1,3,4-Oxadiazin-5(6H)-one Derivatives from Dehydroabietic Acid". . p. 538 - 547. Retrieved 2018/06/11.
• 2、 Kumar, Siripuram Vijay,Ma, Dawei. "Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water". supporting information. p. 1003 - 1006. Retrieved 2018/09/20.