2-Chloro-4-fluorobenzenesulfonyl chloride

Base Information

• Chemical Name: 2-Chloro-4-fluorobenzenesulfonyl chloride
• CAS No.: 85958-57-2
• Molecular Formula: C6H3 Cl2 F O2 S
• Molecular Weight: 229.059
• Hs Code.: 29049090
• Mol file: 85958-57-2.mol

Synonyms:2-Chloro-4-fluorobenzene-1-sulfonylchloride; 2-Chloro-4-fluorobenzenesulfonyl chloride; 2-Chloro-4-fluorophenylsulfonylchloride

Chemical Property of 2-Chloro-4-fluorobenzenesulfonyl chloride

Chemical Property:

• Appearance/Colour: clear yellow liquid after melting
• Vapor Pressure: 0.00277mmHg at 25°C
• Melting Point: 28-31°C
• Refractive Index: n20/D 1.5550(lit.)
• Boiling Point: 294.9 ºCat 760 mmHg
• Flash Point: 132.2 ºC
• PSA: 42.52000
• Density: 1.61 g/cm³
• LogP: 3.48740
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-fluorobenzenesulfonyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-fluorobenzenesulfonyl chloride

There total 3 articles about 2-Chloro-4-fluorobenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,2-bis(2-chloro-4-fluorophenyl)disulfane (132243-22-2) → 2-chloro-4-fluorobenzene-1-sulfonyl chloride (85958-57-2)

Guidance literature:

With hydrogenchloride; chlorine; at 50 - 60 ℃;

DOI:10.1080/00304940509354987

Reference yield:

2-chloro-4-fluoroaniline (2106-02-7) → 2-chloro-4-fluorobenzene-1-sulfonyl chloride (85958-57-2)

Guidance literature:

With hydrogenchloride; sulfur dioxide; acetic acid; sodium nitrite; Yield given. Multistep reaction; 1.) H₂O, 2.) H₂O, RT;

DOI:10.1021/jm00362a017

Reference yield:

→ 2-chloro-4-fluorobenzene-1-sulfonyl chloride (85958-57-2)

Guidance literature:

upstream raw materials:

2-chloro-4-fluoroaniline

1,2-bis(2-chloro-4-fluorophenyl)disulfane

Downstream raw materials:

2-chloro-4-fluorobenzenesulfonamide

N-[3-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-phenyl]-2-chloro-4-fluoro-benzenesulfonamide

C₂₀H₂₃ClFN₅O₂S

4-Chloro-5-sulfamoyl-2-[(thiophen-2-ylmethyl)-amino]-benzenesulfonic acid; compound with C-thiophen-2-yl-methylamine

Refernces

• 1、 -. "Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists". . . Retrieved 2008/06/13.