FMOC-L-PHE(4-COCH3)

Base Information

• Chemical Name: FMOC-L-PHE(4-COCH3)
• CAS No.: 204716-07-4
• Molecular Formula: C26H23 N O5
• Molecular Weight: 429.472
• Mol file: 204716-07-4.mol

Synonyms:Fmoc-D-4-acetylphe;N-Fmoc-L-(p-acetyl-Phe);Fmoc-L-4-Acetylphe;Fmoc-4-Acetyl-L-phenylalanine;

Chemical Property of FMOC-L-PHE(4-COCH3)

Chemical Property:

• Boiling Point: 680.0±55.0 °C(Predicted)
• PKA: 3.65±0.10(Predicted)
• PSA: 92.70000
• Density: 1.282±0.06 g/cm3(Predicted)
• LogP: 4.81450

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-4-acetyl-L-phenylalanine,99.5%(ChiralHPLC) 99.5%(ChiralHPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-L-PHE(4-COCH3)

There total 6 articles about FMOC-L-PHE(4-COCH3) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

p-acetyl-L-phenylalanine (122555-04-8) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → para-acetyl-phenylalanine (204716-07-4,1217751-18-2)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; for 3h;

Reference yield:

para-acetylphenylalanine (18910-27-5,22888-49-9,122555-04-8) → para-acetyl-phenylalanine (204716-07-4,1217751-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic anhydride / 2 h / 20 °C

2.1: Acylase I; cobalt(II) chloride hexahydrate / aq. phosphate buffer / 24 h / 37 °C / Enzymatic reaction

2.2: 0.08 h / 60 °C / pH 8

3.1: sodium hydrogencarbonate / water; acetone / 3 h

With Acylase I; cobalt(II) chloride hexahydrate; acetic anhydride; sodium hydrogencarbonate; In aq. phosphate buffer; water; acetone;

Reference yield:

C13H15NO4 (1403957-00-5) → para-acetyl-phenylalanine (204716-07-4,1217751-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Acylase I; cobalt(II) chloride hexahydrate / aq. phosphate buffer / 24 h / 37 °C / Enzymatic reaction

1.2: 0.08 h / 60 °C / pH 8

2.1: sodium hydrogencarbonate / water; acetone / 3 h

With Acylase I; cobalt(II) chloride hexahydrate; sodium hydrogencarbonate; In aq. phosphate buffer; water; acetone;

upstream raw materials:

para-acetylphenylalanine

C₁₃H₁₅NO₄

p-acetyl-L-phenylalanine

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

p-acetyl-L-phenylalanine

Refernces

• 1、 -. "MACROCYCLIC PEPTIDOMIMETICS FOR ALPHA-HELIX MIMICRY". . . Retrieved 2015/11/02.