1-(2-BROMO-ETHYL)-1H-PYRAZOLE

Base Information

• Chemical Name: 1-(2-BROMO-ETHYL)-1H-PYRAZOLE
• CAS No.: 119291-22-4
• Molecular Formula: C5H7BrN2
• Molecular Weight: 175.028
• Hs Code.: 2933199090
• Mol file: 119291-22-4.mol

Synonyms:1-(2-Bromoethyl)-1H-pyrazole;1-(2-Bromoethyl)pyrazole;

Chemical Property of 1-(2-BROMO-ETHYL)-1H-PYRAZOLE

Chemical Property:

• Vapor Pressure: 0.162mmHg at 25°C
• Refractive Index: 1.584
• Boiling Point: 221.1 °C at 760 mmHg
• PKA: 1.85±0.10(Predicted)
• Flash Point: 87.5 °C
• PSA: 17.82000
• Density: 1.55 g/cm³
• LogP: 1.27800

Purity/Quality:

98%min ^*data from raw suppliers

1-(2-Bromoethyl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-BROMO-ETHYL)-1H-PYRAZOLE

There total 3 articles about 1-(2-BROMO-ETHYL)-1H-PYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

NH-pyrazole (288-13-1) + ethylene dibromide (106-93-4) → 1‐(2‐bromoethyl)‐1H‐pyrazole (119291-22-4)

Guidance literature:

With tetrabutylammomium bromide; In sodium hydroxide; at 20 ℃; for 24h;

DOI:10.1039/b303774f

Reference yield: 72.0%

NH-pyrazole (288-13-1) + ethylene dibromide (106-93-4) → 1‐(2‐bromoethyl)‐1H‐pyrazole (119291-22-4) + 1,2-bis(1H-pyrazol-1-yl)ethane (92146-02-6) + 1-vinylpyrazole (20173-98-2)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; for 24h; Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0968-0896(98)00273-9

Reference yield: 20.0%

NH-pyrazole (288-13-1) + ethylene dibromide (106-93-4) → 1‐(2‐bromoethyl)‐1H‐pyrazole (119291-22-4) + 1,2-bis(1H-pyrazol-1-yl)ethane (92146-02-6)

Guidance literature:

With potassium hydroxide; at 20 ℃; for 48h;

DOI:10.1002/jhet.5570350604

upstream raw materials:

NH-pyrazole

ethylene dibromide

Downstream raw materials:

methyl N-(2-pyrazol-1-yl)ethyliminodiacetate

1-(2-(diphenylphosphino)ethyl)pyrazole

5,6-dihydro-N,10-dimethyl-N-tosylpyrazolo[5,1-a]isoquinolin-8-amine

1-(2-bromoethyl)-4-chloro-1H-pyrazole

Refernces

• 1、 Ovsyannikov,Noamane,Abidi,Ferlay,Solovieva,Antipin,Konovalov,Kyritsakas,Hosseini. "Molecular tectonics: Dimensionality and geometry control of silver coordination networks based on pyrazolyl appended thiacalixarenes". . p. 691 - 703. Retrieved 2016/07/12.
• 2、 Blaszykowski, Christophe,Aktoudianakis, Evangelos,Bressy, Cyril,Alberico, Dino,Lautens, Mark. "Preparation of annulated nitrogen-containing heterocycles via a one-pot palladium-catalyzed alkylation/direct arylation sequence". . p. 2043 - 2045. Retrieved 2007/10/03.