2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde

Base Information

• Chemical Name: 2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde
• CAS No.: 209909-13-7
• Molecular Formula: C10H4 Cl F2 N O
• Molecular Weight: 227.598
• Hs Code.: 29339900
• Mol file: 209909-13-7.mol

Synonyms:2-chloro-6,7-difluoro-3-quinolinecarbaldehyde;2-Chloro-6,7-difluoro-quinoline-3-carbaldehyde;2-chloro-6,7-difluoro-3-quinoline-3-carbaldehyde;2-Chloro-6,7-difluoro-3-quinoline carboxaldehyde;AC-7716;

Chemical Property of 2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 344.847°C at 760 mmHg
• PKA: -3.16±0.50(Predicted)
• Flash Point: 162.358°C
• PSA: 29.96000
• Density: 1.529
• LogP: 2.97890
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde

There total 2 articles about 2-Chloro-6,7-difluoro-3-quinolinecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

3,4-difluoroacetanilide (458-11-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-chloro-6,7-difluoro-3-quinoline-3-carbaldehyde (209909-13-7)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 70 ℃; for 16h;

Reference yield:

→ Acetanilid (103-84-4) + 2-chloro-6,7-difluoro-3-quinoline-3-carbaldehyde (209909-13-7)

Guidance literature:

Reference yield:

trans-(R)-2-[4-(benzyloxymethyl)cyclohexyl]pyrrolidine + 2-chloro-6,7-difluoro-3-quinoline-3-carbaldehyde (209909-13-7) → 2-{(R)-2-[4-(benzyloxymethyl)cyclohexyl]pyrrolidin-1-yl}-6,7-difluoroquinoline-3-carbaldehyde

Guidance literature:

With potassium carbonate; In water; toluene; for 3h; Heating / reflux;

upstream raw materials:

3,4-difluoroacetanilide

N,N-dimethyl-formamide

Downstream raw materials:

5-ethyl-9,10-difluoro-5-hydroxy-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione

Refernces

• 1、 -. "Analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them". . . Retrieved 2008/06/13.
• 2、 -. "Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues". Example 81. . Retrieved 2008/06/13.