6-Chloro-4-methoxynicotinic acid

Base Information

• Chemical Name: 6-Chloro-4-methoxynicotinic acid
• CAS No.: 716362-10-6
• Molecular Formula: C7H6 Cl N O3
• Molecular Weight: 187.583
• Hs Code.: 29339900
• Mol file: 716362-10-6.mol

Synonyms:6-Chloro-4-methoxy-3-pyridinecarboxylic acid

Chemical Property of 6-Chloro-4-methoxynicotinic acid

Chemical Property:

• PSA: 59.42000
• Density: 1.430
• LogP: 1.44180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

6-Chloro-4-methoxyNicotinicAcid ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Chloro-4-methoxynicotinic acid is used for preparation of benzimidazolylazabicyclooctylethylpiperidines as Ccr5 antagonists for the treatment of HIV infection.

Technology Process of 6-Chloro-4-methoxynicotinic acid

There total 7 articles about 6-Chloro-4-methoxynicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 4,6-dichloro-nicotinic acid (73027-79-9) → 6-chloro-4-methoxypyridine-3-carboxylic acid (716362-10-6)

Guidance literature:

methanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.75h;

4,6-dichloro-nicotinic acid; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 17.75h;

DOI:10.1021/ml500137b

Reference yield: 98.0%

methyl 6-chloro-4-methoxypyridine-3-carboxylate (84332-02-5) → 6-chloro-4-methoxypyridine-3-carboxylic acid (716362-10-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 0 - 23 ℃; for 3h;

Reference yield: 49.95%

methanol (67-56-1) + methyl 4,6-dichloropyridine-3-carboxylate (65973-52-6) → 6-chloro-4-methoxypyridine-3-carboxylic acid (716362-10-6)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; at 20 ℃; for 12h;

upstream raw materials:

methanol

4,6-dichloro-nicotinic acid

3-oxopentanedioic acid dimethyl ester

methyl 4,6-dihydroxypyridine-3-carboxylate

Refernces

• 1、 -. "PYRIDINYL PYRAZOLES AS MODULATORS OF RORyT". Paragraph 0461. . Retrieved 2020/01/08.
• 2、 -. "HETEROCYCLIC COMPOUNDS AND USES THEREOF". Paragraph 0424-0426. . Retrieved 2019/04/25.