Benzenemethanol, -alpha-,2,3-trimethyl- (9CI)

Base Information

• Chemical Name: Benzenemethanol, -alpha-,2,3-trimethyl- (9CI)
• CAS No.: 60907-90-6
• Molecular Formula: C10H14O
• Molecular Weight: 150.221
• Mol file: 60907-90-6.mol

Synonyms:1-(2,3-Dimethylphenyl)ethanol;

Chemical Property of Benzenemethanol, -alpha-,2,3-trimethyl- (9CI)

Chemical Property:

• Vapor Pressure: 0.048mmHg at 25°C
• Refractive Index: 1.526
• Boiling Point: 225.8 °C at 760 mmHg
• PKA: 14.71±0.20(Predicted)
• Flash Point: 100 °C
• PSA: 20.23000
• Density: 0.981 g/cm³
• LogP: 2.35670
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Methanol (Sparingly)

Purity/Quality:

99% ^*data from raw suppliers

1-?(2,?3-?Dimethylphenyl)?ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-?(2,?3-?Dimethylphenyl)?ethanol is a reagent used in the synthesis of α-adrenoreceptor agonist used in veterinary medicine for its analgesic and sedative activity. Dexmedetomidine (D299000), an α2-Adrenergic agonist, impurity.

Technology Process of Benzenemethanol, -alpha-,2,3-trimethyl- (9CI)

There total 7 articles about Benzenemethanol, -alpha-,2,3-trimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl magnesium iodide (917-64-6) + 2,3-dimethylbenzaldehyde (5779-93-1) → 1-(2,3-dimethylphenyl)ethanol (60907-90-6)

Guidance literature:

methyl magnesium iodide; 2,3-dimethylbenzaldehyde; In diethyl ether; at 20 ℃; for 3h;

With hydrogenchloride; In diethyl ether; water;

DOI:10.1080/00304948.2015.1005985

Reference yield: 72.0%

1-(2,3-dimethyl-phenyl)-ethanone (2142-71-4) → 1-(2,3-dimethylphenyl)ethanol (60907-90-6)

Guidance literature:

With formic acid; (η6-C10H14)Ru(Ts-ampi)Cl; sodium formate; In water; at 82 ℃; for 0.0166667h;

DOI:10.1002/ejic.201200638

Reference yield:

2,3-dimethylbenzaldehyde (5779-93-1) + methylmagnesium chloride (676-58-4) → 1-(2,3-dimethylphenyl)ethanol (60907-90-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

upstream raw materials:

1-(2,3-dimethyl-phenyl)-ethanone

2,3-dimethylbenzonitrile

1,5-dimethyl-6-methylenetricyclo<3.2.1.0^2,7>oct-3-en-8-one

2,3-dimethylbenzaldehyde

Downstream raw materials:

medetomidine

(S)-dexmedetomidine-L-(+)-tartrate

1-(2,3-dimethyl-phenyl)-ethanone

(+/-)-4(5)-<1-(2,3-Dimethylphenyl)ethyl-1H-imidazole>

Refernces

• 1、 Tuerkmen, Hayati,Cetinkaya, Bekir,Kani, Ibrahim. "Transfer hydrogenation of aryl ketones with half-sandwich RuII complexes that contain chelating diamines". . p. 4494 - 4499,6. Retrieved 2020/08/24.