N-(4-Chloro-3-methoxybenzyl)-2-fluoro-5-methanesulfonylbenzamide

Base Information

• Chemical Name: N-(4-Chloro-3-methoxybenzyl)-2-fluoro-5-methanesulfonylbenzamide
• CAS No.: 247569-57-9
• Molecular Formula: C₁₆H₁₅ClFNO₄S
• Molecular Weight: 371.817
• Mol file: 247569-57-9.mol

Synonyms:N-(4-Chloro-3-methoxybenzyl)-2-fluoro-5-methanesulfonylbenzamide

Chemical Property of N-(4-Chloro-3-methoxybenzyl)-2-fluoro-5-methanesulfonylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-Chloro-3-methoxybenzyl)-2-fluoro-5-methanesulfonylbenzamide

There total 22 articles about N-(4-Chloro-3-methoxybenzyl)-2-fluoro-5-methanesulfonylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Cyanobenzyl alcohol (874-89-5) → N-(4-Chloro-3-methoxybenzyl)-2-fluoro-5-methanesulfonylbenzamide (247569-57-9) + N-Benzyl-2-[2-hydroxy-1-(hydroxymethyl)ethylamino]-5-nitrobenzamide (247567-34-6)

Guidance literature:

Multi-step reaction with 4 steps

3: hydrazine hydrate / ethanol

With hydrazine hydrate; In ethanol;

Reference yield:

2-fluoro-5-(methylsulfonyl)benzoic acid (247569-56-8) + (4-chloro-3-methoxyphenyl)methanamine (247569-42-2) → N-(4-Chloro-3-methoxybenzyl)-2-fluoro-5-methanesulfonylbenzamide (247569-57-9) + N-Benzyl-2-[2-hydroxy-1-(hydroxymethyl)ethylamino]-5-nitrobenzamide (247567-34-6)

Guidance literature:

Reference yield:

2-chloro-5-methylphenol (615-74-7) → N-(4-Chloro-3-methoxybenzyl)-2-fluoro-5-methanesulfonylbenzamide (247569-57-9) + N-Benzyl-2-[2-hydroxy-1-(hydroxymethyl)ethylamino]-5-nitrobenzamide (247567-34-6)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / N-methyl-acetamide

2: N-Bromosuccinimide / dichloromethane

3: N-methyl-acetamide

4: hydrazine hydrate / ethanol

With N-Bromosuccinimide; potassium carbonate; hydrazine hydrate; In N-methyl-acetamide; ethanol; dichloromethane;

upstream raw materials:

2-fluoro-5-(methylsulfonyl)benzoic acid

(4-chloro-3-methoxyphenyl)methanamine

4-chloro-3-ethoxybenzyl bromide

2-{[4-chloro-3-(methyloxy)phenyl]methyl}-1H-isoindole-1,3(2H)-dione

Refernces