Telatinib mesylate

Base Information

• Chemical Name: Telatinib mesylate
• CAS No.: 332013-26-0
• Molecular Formula: CH₄O₃S*C₂₀H₁₆ClN₅O₃
• Molecular Weight: 505.939
• UNII: 571LVA9UMS
• NCI Thesaurus Code: C87837
• Mol file: 332013-26-0.mol

Synonyms:Telatinib mesylate;Telatinib (mesylate);332013-26-0;Telatinib methanesulfonate;571LVA9UMS;332013-24-8;2-Pyridinecarboxamide, 4-(((4-((4-chlorophenyl)amino)furo(2,3-d)pyridazin-7-yl)oxy)methyl)-N-methyl-, methanesulphonate (1:1);2-Pyridinecarboxamide,4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-, mono(4-methylbenzenesulfonate);4-[[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methylpyridine-2-carboxamide;methanesulfonic acid;UNII-571LVA9UMS;SCHEMBL4042879;HY-10527C;MS-29400;CS-0025251;F78022;4-(((4-((4-Chlorophenyl)amino)furo[2,3-d]pyridazin-7-yl)oxy)methyl)-N-methylpicolinamide methanesulfonate;4-((t 4-((4-Chlorophenyl))aminofuro(2,3- djpyridazin-7-yl joxy)methyl)-N-methyl-2-pyridinecarboxamide methanesulfonate

Chemical Property of Telatinib mesylate

Chemical Property:

• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 6
• Exact Mass: 505.0822822
• Heavy Atom Count: 34
• Complexity: 641

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNC(=O)C1=NC=CC(=C1)COC2=NN=C(C3=C2OC=C3)NC4=CC=C(C=C4)Cl.CS(=O)(=O)O
• Recent ClinicalTrials: Telatinib Safety and Pharmacokinetics Study in China Patients With Advanced Solid Tumors

Technology Process of Telatinib mesylate

There total 3 articles about Telatinib mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.4%

Telatinib (332012-40-5) + methanesulfonic acid (75-75-2,98527-29-8) → 4-[({4-[(4-chlorophenyl)amino]furan[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide methanesulfonate (332013-26-0)

Guidance literature:

In methanol; for 0.25h; Autoclave; Reflux; Large scale;

Reference yield:

ethyl 2-methylaminocarbonyl-4-picolinate (332013-42-0) → 4-[({4-[(4-chlorophenyl)amino]furan[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide methanesulfonate (332013-26-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / isopropyl alcohol; methanol / 8 h / 25 °C / Large scale

1.2: 1 h / 0 °C / Large scale

2.1: potassium tert-butylate / toluene; tetrahydrofuran / 24 h / 95 °C / Autoclave

3.1: methanol / 0.25 h / Autoclave; Reflux; Large scale

With sodium tetrahydroborate; potassium tert-butylate; In tetrahydrofuran; methanol; isopropyl alcohol; toluene;

Reference yield:

→ 4-[({4-[(4-chlorophenyl)amino]furan[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide methanesulfonate (332013-26-0)

Guidance literature:

upstream raw materials:

Telatinib

methanesulfonic acid

ethyl 2-methylaminocarbonyl-4-picolinate

Refernces

• 1、 -. "SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY". Page/Page column 64. . Retrieved 2009/03/07.
• 2、 -. "Substituted pyridines and pyridazines with angiogenesis inhibiting activity". Page column 101-104. . Retrieved 2010/02/05.