1-Acetyl-3-indolinone

Base Information

• Chemical Name: 1-Acetyl-3-indolinone
• CAS No.: 16800-68-3
• Molecular Formula: C10H9NO2
• Molecular Weight: 175.187
• Hs Code.: 2933990090
• Mol file: 16800-68-3.mol

Synonyms:Pseudoindoxyl, 1-acetyl- (6CI);1-Acetyl-1,2-dihydro-3H-indol-3-one;1-Acetyl-1,2-dihydroindol-3-one;1-Acetyl-3-oxo-2,3-dihydroindole;1-Acetyl-3-oxoindole;1-Acetylindol-3(2H)-one;1-Acetylpseudoindoxyl;N-Acetyl-3-indolinone;3-Indolinone,1-acetyl- (8CI);

Chemical Property of 1-Acetyl-3-indolinone

Chemical Property:

• Vapor Pressure: 5.68E-07mmHg at 25°C
• Melting Point: 133-134 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Refractive Index: 1.595
• Boiling Point: 411.2 °C at 760 mmHg
• PKA: -1.85±0.20(Predicted)
• Flash Point: 211.2 °C
• PSA: 37.38000
• Density: 1.275 g/cm³
• LogP: 1.30080
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Acetylindolin-3-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Acetyl-3-indolinone

There total 32 articles about 1-Acetyl-3-indolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

cis-1-acetyl-3-hydroxy-2-methoxyindoline (87066-86-2,87073-73-2,129052-49-9) → 1-acetyl-2,3-dihydro-1H-indol-3-one (16800-68-3)

Guidance literature:

With tin(IV) chloride; In dichloromethane; Ambient temperature;

Reference yield: 99.0%

1-acetyl-trans-3-hydroxy-2-methoxyindole (87066-86-2,87073-73-2,129052-49-9) → 1-acetyl-2,3-dihydro-1H-indol-3-one (16800-68-3)

Guidance literature:

With tin(IV) chloride; In dichloromethane; for 0.5h; Ambient temperature;

Reference yield: 90.0%

1-acetil-2-(4-nitrobenzoil)indolin-3-one (82670-67-5) → 1-acetyl-2,3-dihydro-1H-indol-3-one (16800-68-3)

Guidance literature:

With triethylamine; In methanol; benzene; for 17h; Heating;

upstream raw materials:

3-hydroxy-1H-indole-2-carboxylic acid

acetic anhydride

indoxyl

N-acetylindole

Downstream raw materials:

N,O-diacetylindoxyl

1-acetyl-indolin-3-one-phenylhydrazone

1-Acetyl-2,3-dihydro-1H-indole

indole-2,3-dione

Refernces

• 1、 Fei, Xing-Hai,Guan, Xiang,He, Bin,Li, Zong-Qin,Wang, Da-Peng,Yang, Fen-Fen,Yang, Yuan-Yong,Zhao, Yong-Long,Zhou, Meng. "Construction of Oxepino[3,2-b]indoles via [4+3] Annulation of 2-Ylideneoxindoles with Crotonate-Derived Sulfur Ylides". supporting information. p. 3018 - 3024. Retrieved 2021/06/26.
• 2、 Schwertz, Geoffrey,Witschel, Matthias C.,Rottmann, Matthias,Leartsakulpanich, Ubolsree,Chitnumsub, Penchit,Jaruwat, Aritsara,Amornwatcharapong, Watcharee,Ittarat, Wanwipa,Sch?fer, Anja,Aponte, Raphael A.,Trapp, Nils,Chaiyen, Pimchai,Diederich, Fran?ois. "Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold". supporting information. p. 931 - 943. Retrieved 2018/04/20.