4-Amino-3-bromoquinoline

Base Information

• Chemical Name: 4-Amino-3-bromoquinoline
• CAS No.: 36825-36-2
• Molecular Formula: C9H7BrN2
• Molecular Weight: 223.072
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID30355792
• Nikkaji Number: J89.129K
• Wikidata: Q27453134
• Mol file: 36825-36-2.mol

Synonyms:4-amino-3-bromoquinoline;36825-36-2;3-bromoquinolin-4-amine;3-BROMO-QUINOLIN-4-YLAMINE;MFCD00234502;3-Bromo-4-aminoquinoline;AC-907/25004883;SCHEMBL439796;(3-bromo-quinolin-4-yl)-amine;DTXSID30355792;AKOS015854758;CS-W002562;DS-0271;FS-3276;SB36856;AC-23724;SY021107;AM20051119;FT-0648254;A26214;EN300-203970;J-514351;Q27453134;F2167-2354;2NW

Chemical Property of 4-Amino-3-bromoquinoline

Chemical Property:

• Vapor Pressure: 5.61E-05mmHg at 25°C
• Melting Point: 203°C
• Refractive Index: 1.732
• Boiling Point: 346.8 °C at 760 mmHg
• Flash Point: 163.5 °C
• PSA: 38.91000
• Density: 1.649 g/cm³
• LogP: 3.16070
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 221.97926
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-3-bromoquinoline ^*data from reagent suppliers

Safty Information:

• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=C(C=N2)Br)N
• Uses: 4-Amino-3-bromoquinoline is a useful research intermediate for the preparation of aminoquinolines.

Technology Process of 4-Amino-3-bromoquinoline

There total 10 articles about 4-Amino-3-bromoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-aminoquinoline (578-68-7) → 3-bromo-quinolin-4-ylamine (36825-36-2)

Guidance literature:

With bromine; acetic acid; for 1h;

DOI:10.1021/acs.joc.1c02026

Reference yield: 82.0%

→ 4-aminoquinoline (578-68-7) + 3-bromo-quinolin-4-ylamine (36825-36-2)

Guidance literature:

Reference yield:

→ 3-bromo-quinolin-4-ylamine (36825-36-2)

Guidance literature:

With sulfuric acid; at 180 - 190 ℃;

DOI:10.1021/ja01195a501

upstream raw materials:

4-aminoquinoline

chloroform

bromine

acetic acid

Downstream raw materials:

3-bromoquinoline

Refernces

• 1、 Akitake, Masahiro,Miyoshi, Kohei,Noda, Shizuki,Sonoda, Motohiro,Tanimori, Shinji. "Access to γ-Carbolines: Synthesis of Isocryptolepine". . p. 17727 - 17737. Retrieved 2021/12/17.
• 2、 -. "Amide derivatives and nociceptin antagonists". . . Retrieved 2008/06/13.