Dexamethasone-17,20 21-Aldehyde

Base Information

• Chemical Name: Dexamethasone-17,20 21-Aldehyde
• CAS No.: 6762-51-2
• Molecular Formula: C₂₂H₂₇FO₄
• Molecular Weight: 374.452
• Mol file: 6762-51-2.mol

Synonyms:C₂₂H₂₇FO₄

Chemical Property of Dexamethasone-17,20 21-Aldehyde

Chemical Property:

• Melting Point: 226-230°C
• Storage Temp.: -20?C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

98% ^*data from raw suppliers

Dexamethasone-?17,2021-Aldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A degradation and metabolic intermediate of Dexamethasone (D298800). A Dexamethasone enol aldehyde as inflammation inhibitor. A degradation and metabolic intermediate of Dexamethasone (D298800). A Dexamethasone enol aldehyde as inflammation inhibitor

Technology Process of Dexamethasone-17,20 21-Aldehyde

There total 4 articles about Dexamethasone-17,20 21-Aldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dexamethasone 17,21-dipropionate (55541-30-5) → C22H27FO4 (6762-51-2) + dexamethasone 21-propionate (3793-10-0)

Guidance literature:

With sodium hydroxide; In water; acetonitrile; at 20 ℃; for 0.666667h;

DOI:10.1016/j.steroids.2008.09.009

Reference yield:

→ [(9R,10S,11S,13S,16S)-9-Fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-3,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-cyclopenta[a]phenanthren-(17E)-ylidene]-hydroxy-acetaldehyde (6762-45-4,6762-51-2,52647-06-0,52647-07-1)

Guidance literature:

Betamethason-17-valerat, K-t-butylat, THF;

Reference yield:

→ [(R)-9-Fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-3,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-cyclopenta[a]phenanthren-(17E)-ylidene]-hydroxy-acetaldehyde (6762-45-4,6762-51-2,52647-06-0,52647-07-1)

Guidance literature:

9-Fluor-11β,17,21-trihydroxy-16α-methyl-1,4-pregnadien-3,20-dion, Zinkacetat-dihydrat/Eisessig;

upstream raw materials:

dexamethasone 17,21-dipropionate

Downstream raw materials:

dexamethasone

Refernces