2-ACETAMIDO-4,6-O-BENZYLIDENE-2-DEOXY-D-GLUCONHYDROXIMO-1,5-LACTONE

Base Information

• Chemical Name: 2-ACETAMIDO-4,6-O-BENZYLIDENE-2-DEOXY-D-GLUCONHYDROXIMO-1,5-LACTONE
• CAS No.: 132063-03-7
• Molecular Formula: C15H18 N2 O6
• Molecular Weight: 322.315
• Mol file: 132063-03-7.mol

Synonyms:D-Gluconimidicacid, 2-(acetylamino)-2-deoxy-N-hydroxy-4,6-O-(phenylmethylene)-, d-lactone,(R)-; Pyrano[3,2-d]-1,3-dioxin, D-gluconimidic acid deriv.

Chemical Property of 2-ACETAMIDO-4,6-O-BENZYLIDENE-2-DEOXY-D-GLUCONHYDROXIMO-1,5-LACTONE

Chemical Property:

• Melting Point: 229-231°C
• PSA: 109.61000
• LogP: 0.54360

Purity/Quality:

99% ^*data from raw suppliers

2-Acetamido-4,6-O-benzylidene-2-deoxy-D-gluconhydroximo-1,5-lactone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Acetamido-4,6-O-benzylidene-2-deoxy-D-gluconohydroximo-1,5-lactone is used in synthesis of 2-acetamido-2-deoxy-D-gluconohydroximolactone (PUGNAc), a strong inhibitor of β-N-acetylglucosaminidases.

Technology Process of 2-ACETAMIDO-4,6-O-BENZYLIDENE-2-DEOXY-D-GLUCONHYDROXIMO-1,5-LACTONE

There total 1 articles about 2-ACETAMIDO-4,6-O-BENZYLIDENE-2-DEOXY-D-GLUCONHYDROXIMO-1,5-LACTONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N-[(1R,2R)-2-Hydroxy-1-(hydroxyimino-methyl)-2-((2R,4S,5R)-5-hydroxy-2-phenyl-[1,3]dioxan-4-yl)-ethyl]-acetamide (105874-58-6) → 2-acetamido-4,6-O-benzylidene-2-deoxy-D-gluconhydroximo-1,5-lactone (132063-03-7)

Guidance literature:

With manganese(IV) oxide; In methanol; at 50 ℃;

DOI:10.1002/hlca.19900730714

Reference yield: 86.0%

2-acetamido-4,6-O-benzylidene-2-deoxy-D-gluconhydroximo-1,5-lactone (132063-03-7) → 2-acetamido-2-deoxy-D-gluconhydroximo-1,5-lactone (132152-76-2)

Guidance literature:

With ammonia; sodium; at -35 ℃;

DOI:10.1002/hlca.19900730714

upstream raw materials:

N-[(1R,2R)-2-Hydroxy-1-(hydroxyimino-methyl)-2-((2R,4S,5R)-5-hydroxy-2-phenyl-[1,3]dioxan-4-yl)-ethyl]-acetamide

Downstream raw materials:

2-acetamido-2-deoxy-D-gluconhydroximo-1,5-lactone

Refernces