Technology Process of (R)-N4-benzyloxy-2-butyl-N1-{(S)-1-[4-(4-fluoro-benzenesulfonylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-succinamide
There total 8 articles about (R)-N4-benzyloxy-2-butyl-N1-{(S)-1-[4-(4-fluoro-benzenesulfonylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-succinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: triethylamine / methanol / 5 h / 65 °C
1.2: 48 h
2.1: hydrogen / palladium 10% on activated carbon / ethanol / 5320.36 Torr
3.1: triethylamine / water; acetonitrile / 5 h / 20 °C
4.1: hydrogenchloride / ethyl acetate
5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
6.1: hydrogenchloride / ethyl acetate
7.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
8.1: hydrogenchloride / ethyl acetate
9.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
With
hydrogenchloride; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: hydrogen / palladium 10% on activated carbon / ethanol / 5320.36 Torr
2: triethylamine / water; acetonitrile / 5 h / 20 °C
3: hydrogenchloride / ethyl acetate
4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
5: hydrogenchloride / ethyl acetate
6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
7: hydrogenchloride / ethyl acetate
8: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
With
hydrogenchloride; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
palladium 10% on activated carbon;
In
ethanol; dichloromethane; water; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogenchloride / ethyl acetate
2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
3: hydrogenchloride / ethyl acetate
4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
5: hydrogenchloride / ethyl acetate
6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C
With
hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane; ethyl acetate;