Benzimidazole, 2-(2-thiazolyl)-

Base Information

• Chemical Name: Benzimidazole, 2-(2-thiazolyl)-
• CAS No.: 3574-94-5
• Molecular Formula: C10H7N3S
• Molecular Weight: 201.25
• DSSTox Substance ID: DTXSID40189282
• Nikkaji Number: J2.815.858K
• Wikidata: Q83061312
• Mol file: 3574-94-5.mol

Synonyms:2-(2-Thiazolyl)benzimidazole;Benzimidazole, 2-(2-thiazolyl)-;3574-94-5;benzimidazolylthiazole;SCHEMBL1021801;DTXSID40189282;2-(2-Thiazolyl)-1H-benzoimidazole;FT-0752300

Chemical Property of Benzimidazole, 2-(2-thiazolyl)-

Chemical Property:

• Vapor Pressure: 8.63E-08mmHg at 25°C
• Refractive Index: 1.739
• Boiling Point: 435.6 °C at 760 mmHg
• Flash Point: 219.5 °C
• Density: 1.406 g/cm³
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 201.03606841
• Heavy Atom Count: 14
• Complexity: 212

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)NC(=N2)C3=NC=CS3

Technology Process of Benzimidazole, 2-(2-thiazolyl)-

There total 3 articles about Benzimidazole, 2-(2-thiazolyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

→ 2-(2-thiazolyl)-benzimidazole (3574-94-5)

Guidance literature:

With caesium carbonate; In water; at 50 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

Thiazole-2-carbaldehyde (10200-59-6) + 1,2-diamino-benzene (95-54-5) → 2-(2-thiazolyl)-benzimidazole (3574-94-5)

Guidance literature:

Thiazole-2-carbaldehyde; 1,2-diamino-benzene; In N,N-dimethyl-formamide; for 0.0833333h; Inert atmosphere;

With sodium metabisulfite; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

Reference yield:

2-(4,5-dihydro-thiazol-2-yl)-1H-benzoimidazole (10090-27-4) → 2-(2-thiazolyl)-benzimidazole (3574-94-5)

Guidance literature:

palladium on activated charcoal; In diphenylether; for 16h; Heating;

DOI:10.1039/j39670000033

upstream raw materials:

2-(4,5-dihydro-thiazol-2-yl)-1H-benzoimidazole

Thiazole-2-carbaldehyde

1,2-diamino-benzene

Downstream raw materials:

C₁₈H₁₂Cl₂N₄OS

C₁₈H₁₃BrN₄OS

C₁₈H₁₃ClN₄OS

Rh(H)2(PPh₃)2(2-(4-thiazolyl)benzimidazole)ClO₄

Refernces

• 1、 Kirubakaran, Sivapriya,Gorla, Suresh Kumar,Sharling, Lisa,Zhang, Minjia,Liu, Xiaoping,Ray, Soumya S.,MacPherson, Iain S.,Striepen, Boris,Hedstrom, Lizbeth,Cuny, Gregory D.. "Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH". scheme or table. p. 1985 - 1988. Retrieved 2012/04/05.