4,6-bis(3,5-dichlorophenyl)-2-methylpyrimidine

Base Information

• Chemical Name: 4,6-bis(3,5-dichlorophenyl)-2-methylpyrimidine
• CAS No.: 1030380-50-7
• Molecular Formula: C₁₇H₁₀Cl₄N₂
• Molecular Weight: 384.092
• Mol file: 1030380-50-7.mol

Synonyms:4,6-bis(3,5-dichlorophenyl)-2-methylpyrimidine

Chemical Property of 4,6-bis(3,5-dichlorophenyl)-2-methylpyrimidine

Chemical Property:

• Melting Point: 230-231 °C(Solv: toluene (108-88-3))
• Boiling Point: 508.3±45.0 °C(Predicted)
• Density: 1.419±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

4,6-Bis(3,5-dichlorophenyl)-2-methylpyrimidine 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6-bis(3,5-dichlorophenyl)-2-methylpyrimidine

There total 1 articles about 4,6-bis(3,5-dichlorophenyl)-2-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,4-dichloro-2-methylpyrimidine (1780-26-3) + (3,5-dichlorophenyl)boronic acid (67492-50-6) → 4,6-bis(3,5-dichlorophenyl)-2-methylpyrimidine (1030380-50-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; acetonitrile; at 60 ℃; for 6h; Inert atmosphere;

DOI:10.1002/adfm.201001252

Reference yield: 61.0%

4,6-bis(3,5-dichlorophenyl)-2-methylpyrimidine (1030380-50-7) + bis(pinacol)diborane (73183-34-3) → C41H58B4N2O8 (1266181-48-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; tricyclohexylphosphine; In 1,4-dioxane; for 18h; Inert atmosphere; Reflux;

DOI:10.1002/adfm.201001252

Reference yield:

4,6-bis(3,5-dichlorophenyl)-2-methylpyrimidine (1030380-50-7) + 4-pyridineboronic acid pinacol ester (181219-01-2) → 4,6-bis(3,5-di(pyridin-4-yl)phenyl)-2-methylpyrimidine (1030380-51-8)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; for 30h; Inert atmosphere; Reflux;

DOI:10.1002/adfm.201001252

upstream raw materials:

2,4-dichloro-2-methylpyrimidine

(3,5-dichlorophenyl)boronic acid

Downstream raw materials:

C₄₁H₅₈B₄N₂O₈

4,6-bis(3,5-di(pyridin-4-yl)phenyl)-2-methylpyrimidine

Refernces

• 1、 Tumkevicius,Dodonova,Baskirova,Voitechovicius. "Palladium-catalyzed cross-coupling reaction of 2- and/or 5-substituted 4,6-dichloropyrimidines with arylboronic acids". experimental part. p. 960 - 964. Retrieved 2009/12/06.