6-(AMINOMETHYL)-2-PYRIDINE CARBOXYLIC ACID

Base Information

• Chemical Name: 6-(AMINOMETHYL)-2-PYRIDINE CARBOXYLIC ACID
• CAS No.: 160939-10-6
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Hs Code.: 29333990
• Mol file: 160939-10-6.mol

Synonyms:6-Aminomethyl-2-pyridinecarboxylic acid;6-(Aminomethyl)pyridine-2-carboxylic acid;

Chemical Property of 6-(AMINOMETHYL)-2-PYRIDINE CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.42E-05mmHg at 25°C
• Refractive Index: 1.606
• Boiling Point: 352.407 °C at 760 mmHg
• PKA: 8.43±0.39(Predicted)
• Flash Point: 166.93 °C
• PSA: 76.21000
• Density: 1.321 g/cm³
• LogP: 0.93880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl6-(aminomethyl)picolinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(AMINOMETHYL)-2-PYRIDINE CARBOXYLIC ACID

There total 8 articles about 6-(AMINOMETHYL)-2-PYRIDINE CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-pyridine-2-carboxylic acid methyl ester → methyl 6-(aminomethyl)picolinate (160939-10-6)

Guidance literature:

With hydrazine hydrate; In methanol; chloroform; Reflux;

Reference yield:

methyl 6-(bromomethyl)picolinate (146462-25-1) → methyl 6-(aminomethyl)picolinate (160939-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 5 h / 20 °C

2: hydrazine hydrate / methanol; chloroform / Reflux

With hydrazine hydrate; In methanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

pyridine-2-carbaldehyde (1121-60-4) + citric acid (77-92-9,906507-37-7) → methyl 6-(aminomethyl)picolinate (160939-10-6)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol;

upstream raw materials:

pyridine-2-carbaldehyde

citric acid

2,6-dimethylpyridine

6-methyl-2-pyridinecarboxylic acid

Downstream raw materials:

6-{[(tertbutoxycarbonyl)amino]methyl}-2-pyridinecarboxylic acid

Refernces

• 1、 -. "Polysubstituted pyridine medical intermediate and synthetic method thereof". . . Retrieved 2016/10/08.