Technology Process of 2-(3,4-Difluorophenyl)indole
There total 5 articles about 2-(3,4-Difluorophenyl)indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
2: potassium carbonate; L-proline; copper(I) bromide / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; diisopropylamine; L-proline; copper(I) bromide;
In
dimethyl sulfoxide; N,N-dimethyl-formamide;
1: Sonogashira coupling;
DOI:10.1016/j.tetlet.2012.06.023
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium nitrite; acetic acid / water / 0 °C
1.2: 0 - 20 °C
2.1: tris(bipyridine)ruthenium(II) dichloride hexahydrate / N,N-dimethyl-formamide / 24 h / 20 °C / Schlenk technique; Irradiation
With
tris(bipyridine)ruthenium(II) dichloride hexahydrate; acetic acid; sodium nitrite;
In
water; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201400527
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium diacetate; triethylamine / acetonitrile / 2 h / 100 °C / Inert atmosphere; Schlenk technique
2.1: sodium nitrite; acetic acid / water / 0 °C
2.2: 0 - 20 °C
3.1: tris(bipyridine)ruthenium(II) dichloride hexahydrate / N,N-dimethyl-formamide / 24 h / 20 °C / Schlenk technique; Irradiation
With
tris(bipyridine)ruthenium(II) dichloride hexahydrate; palladium diacetate; acetic acid; triethylamine; sodium nitrite;
In
water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/adsc.201400527