5-CHLORO INDAZOLE-3-CARBOXALDEHYDE

Base Information

• Chemical Name: 5-CHLORO INDAZOLE-3-CARBOXALDEHYDE
• CAS No.: 102735-84-2
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.593
• Hs Code.: 29339900
• Mol file: 102735-84-2.mol

Synonyms:5-Chloro-1H-indazole-3-carboxaldehyde;

Chemical Property of 5-CHLORO INDAZOLE-3-CARBOXALDEHYDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.748
• Boiling Point: 391.695 °C at 760 mmHg
• PKA: 10.85±0.40(Predicted)
• Flash Point: 190.691 °C
• PSA: 45.75000
• Density: 1.521 g/cm³
• LogP: 2.02880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

5-Chloro-1H-indazole-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO INDAZOLE-3-CARBOXALDEHYDE

There total 6 articles about 5-CHLORO INDAZOLE-3-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-chloro-1H-indole (17422-32-1) → 5-chloro-1H-indazole-3-carbaldehyde (102735-84-2)

Guidance literature:

With hydrogenchloride; water; sodium nitrite; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1039/c8ra01546e

Reference yield: 66.0%

5-chloro-3-(hydroxymethyl)indazole (102735-90-0) → 5-chloro-1H-indazole-3-carbaldehyde (102735-84-2)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 1h; Heating;

DOI:10.1021/ja00274a043

Reference yield: 31.0%

5-chloro-1H-indole (754948-43-1) → 5-chloro-1H-indazole-3-carbaldehyde (102735-84-2)

Guidance literature:

With hydrogenchloride; sodium nitrite; for 1h; Ambient temperature;

DOI:10.1021/ja00274a043

upstream raw materials:

5-chloro-1H-indole

5-chloro-3-(hydroxymethyl)indazole

5-chloro-1H-indazole-3-carboxylic acid

5-chloro-1H-indole

Refernces

• 1、 -. "ANTICANCER AGENT". Paragraph 0359. . Retrieved 2013/03/26.
• 2、 Buechi, George,Lee, Gary C. M.,Yang, David,Tannenbaum, Steven R.. "Direct Acting, Highly Mutagenic, α-Hydroxy N-Nitrosamines from 4-Chloroindoles". . p. 4115 - 4119. Retrieved 2007/10/02.