2-Iodophenylmethylthioacetic acid

Base Information

• Chemical Name: 2-Iodophenylmethylthioacetic acid
• CAS No.: 867202-85-5
• Molecular Formula: C9H9 I O2 S
• Molecular Weight: 308.14
• Mol file: 867202-85-5.mol

Synonyms:Aceticacid, [[(2-iodophenyl)methyl]thio]- (9CI)

Chemical Property of 2-Iodophenylmethylthioacetic acid

Chemical Property:

• PSA: 62.60000
• Density: 1.818
• LogP: 2.60900

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Iodophenylmethylthioacetic acid

There total 5 articles about 2-Iodophenylmethylthioacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

sodium monochloroacetic acid (3926-62-3) → (2-iodo-benzylsulfanyl)-acetic acid (867202-85-5)

Guidance literature:

2-Iodobenzyl bromide; With thiourea; In water; at 60 ℃; for 0.5h; Heating / reflux;

With sodium hydroxide; In water; at 60 ℃; for 0.0833333h; Heating / reflux;

sodium monochloroacetic acid; In water; at 110 ℃; for 1h;

Reference yield: 80.0%

2-(2-iodo-benzyl)-isothiourea + chloroacetic acid (79-11-8) → (2-iodo-benzylsulfanyl)-acetic acid (867202-85-5)

Guidance literature:

2-(2-iodo-benzyl)-isothiourea; With sodium hydroxide; at 80 ℃; for 1h;

chloroacetic acid; for 2h; Reflux;

DOI:10.1016/j.bmcl.2011.12.099

Reference yield:

2-iodobenzyl alcohol (5159-41-1) → (2-iodo-benzylsulfanyl)-acetic acid (867202-85-5)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen bromide / water / 0.5 h / 60 °C / Reflux

2: sodium hydroxide / 1 h / 80 °C

3: 2 h / Reflux

With hydrogen bromide; sodium hydroxide; In water;

DOI:10.1016/j.bmcl.2012.01.064

upstream raw materials:

sodium monochloroacetic acid

2-iodobenzyl alcohol

chloroacetic acid

Downstream raw materials:

C₁₇H₁₄O₂S₂

C₉H₉IO₃S

methyl (2-iodobenzylthio)acetate

2-(2-iodo-benzylsulfanyl)-acetamide

Refernces

• 1、 Lesur, Brigitte,Lin, Yin G.,Marcy, Val R.,Aimone, Lisa D.,Gruner, John,Bacon, Edward R.,Chatterjee, Sankar. "Aryl-Heteroaryl Derivatives as Novel Wake-Promoting Agents". . p. 429 - 432. Retrieved 2013/03/29.
• 2、 -. "Biaryl-methanethio-, -sulphinyl- and sulphonyl derivatives". Page/Page column 22. . Retrieved 2008/06/13.