Boronic acid, [4-(difluoromethoxy)phenyl]- (9CI)

Base Information

• Chemical Name: Boronic acid, [4-(difluoromethoxy)phenyl]- (9CI)
• CAS No.: 688810-12-0
• Molecular Formula: C7H7BF2O3
• Molecular Weight: 187.939
• Hs Code.: 2931900090
• Mol file: 688810-12-0.mol

Synonyms:Boronicacid, [4-(difluoromethoxy)phenyl]- (9CI);4-Difluoromethoxybenzeneboronic acid;

Chemical Property of Boronic acid, [4-(difluoromethoxy)phenyl]- (9CI)

Chemical Property:

• Vapor Pressure: 0.000521mmHg at 25°C
• Refractive Index: 1.478
• Boiling Point: 299.8 °C at 760 mmHg
• PKA: 8.41±0.16(Predicted)
• Flash Point: 135.1 °C
• PSA: 49.69000
• Density: 1.33 g/cm³
• LogP: -0.03220
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

4-(Difluoromethoxy)phenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(Difluoromethoxy)phenylboronic acid

Technology Process of Boronic acid, [4-(difluoromethoxy)phenyl]- (9CI)

There total 1 articles about Boronic acid, [4-(difluoromethoxy)phenyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (4-(difluoromethoxy)phenyl)boronic acid (688810-12-0)

Guidance literature:

Reference yield: 96.1%

(4-(difluoromethoxy)phenyl)boronic acid (688810-12-0) + 1-(4-amino-2-methyl-phenyl)-pyrrolidin-2-one (13691-29-7) → 8-chloro-3-(4-(difluoromethoxyl)phenyl)imidazo[1,2-a]pyrazine

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 15h; Inert atmosphere;

Reference yield: 91.0%

(4-(difluoromethoxy)phenyl)boronic acid (688810-12-0) + (6R)-6-[(5-bromopyridin-2-yl)methoxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine → (6R)-6-({5-[4-(difluoromethoxy)phenyl]pyridin-2-yl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In ethanol; water; N,N-dimethyl-formamide; toluene; at 88 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b01581

Downstream raw materials:

(6S)-6-({5-[4-(difluoromethoxy)phenyl]-2-thienyl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

(6S)-6-({2-[4-(difluoromethoxy)phenyl]-5-pyrimidinyl}methoxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

(6S)-6-({(2E)-3-[4'-(difluoromethoxy)[1,1'-biphenyl]-4-yl]-2-propenyl}oxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

(6S)-6-({3-[4'-(difluoromethoxy)[1,1'-biphenyl]-4-yl]-2-propynyl}oxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Refernces