6-Methyl-2-phenylbenzofuran

Base Information

• Chemical Name: 6-Methyl-2-phenylbenzofuran
• CAS No.: 33008-48-9
• Molecular Formula: C₁₅H₁₂O
• Molecular Weight: 208.26
• Mol file: 33008-48-9.mol

Synonyms:6-Methyl-2-phenylbenzofuran

Chemical Property of 6-Methyl-2-phenylbenzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Methyl-2-phenylbenzofuran

There total 25 articles about 6-Methyl-2-phenylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.32%

C16H14O4 → 6-Methyl-2-phenylbenzofuran (33008-48-9)

Guidance literature:

With sodium acetate; acetic anhydride; at 120 - 125 ℃; for 4h;

DOI:10.1080/14756366.2021.1940993

Reference yield: 85.0%

6-iodo-3-methyl-phenol (35928-80-4) + phenylacetylene (536-74-3) → 6-Methyl-2-phenylbenzofuran (33008-48-9)

Guidance literature:

With caesium carbonate; (1,10-phenanthroline)bis(triphenylphosphine)copper(I) nitrate; In toluene; at 110 ℃; for 24h;

DOI:10.1055/s-2005-869893

Reference yield: 85.0%

C15H13BrO → 6-Methyl-2-phenylbenzofuran (33008-48-9)

Guidance literature:

With potassium carbonate; palladium dichloride; In N,N-dimethyl-formamide; at 130 ℃; for 6h; under air; sealed tube;

DOI:10.1021/ol202383z

upstream raw materials:

4-methylsalicylaldehyde

Chloro-phenyl-acetic acid

alpha-(3-methylphenoxy)acetophenone

β-(6-methyl-2-phenyl-6,7-dihydrobenzofuran-4-ylthio)propionic acid

Downstream raw materials:

methyl 2-(benzoyloxy)-4-methylbenzoate

C₃₀H₂₆O₆

1,2-Bis-(2-hydroxy-4-methyl-phenyl)-ethane-1,2-dione

4-methyl-bibenzyl-2-ol

Refernces

• 1、 Wen, Chang,Wu, Chuan,Luo, Ruiqiang,Li, Qinghan,Chen, Feng. "Highly Efficient Synthesis of 2-Substituted Benzo[ b ]furan Derivatives from the Cross-Coupling Reactions of 2-Halobenzo[ b ]furans with Organoalane Reagents". . p. 3847 - 3861. Retrieved 2021/07/02.
• 2、 Li, Yibiao,Cheng, Liang,Liu, Xiaohang,Li, Bin,Sun, Ning. "Copper-promoted hydration and annulation of 2-fluorophenylacetylene derivatives: From alkynes to benzo[b]furans and benzo[b]thiophenes". supporting information. p. 2886 - 2891. Retrieved 2015/02/19.