3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, ethyl ester

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, ethyl ester
• CAS No.: 27805-12-5
• Molecular Formula: C8H9 N O3
• Molecular Weight: 167.16
• Hs Code.: 2933399090
• Mol file: 27805-12-5.mol

Synonyms:Nicotinicacid, 1,2-dihydro-2-oxo-, ethyl ester (7CI); Nicotinic acid, 2-hydroxy-, ethylester (8CI); 2-Hydroxynicotinic acid ethyl ester; Ethyl 2-hydroxynicotinate

Chemical Property of 3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, ethyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 369.661°C at 760 mmHg
• Flash Point: 177.365°C
• PSA: 59.42000
• Density: 1.214g/cm³
• LogP: 0.96390
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

ethyl2-oxo-1,2-dihydropyridine-3-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, ethyl ester

There total 10 articles about 3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethanol (64-17-5) + 2-hydroxynicotinic acid chloride (28369-76-8) → 2-hydroxyl nicotinic acid ethyl ester (27805-12-5)

Guidance literature:

for 12h; Ambient temperature;

DOI:10.1039/a706533g

Reference yield: 42.0%

1-p-tolylpyrimidin-2(1H)-one (17758-14-4) + diethyl malonate (105-53-3) → ethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile (27805-12-5)

Guidance literature:

With sodium ethanolate; In ethanol; for 1h; Ambient temperature;

Reference yield: 27.0%

1-phenyl-2(1H)-pyrimidinone (17758-13-3) + diethyl malonate (105-53-3) → ethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile (27805-12-5)

Guidance literature:

With sodium ethanolate; In ethanol; for 4h; Ambient temperature;

upstream raw materials:

2-hydroxy-3-carboxypyridine

ethanol

2-hydroxynicotinic acid chloride

piperidine

Downstream raw materials:

1,2-dihydro-2-oxopyridine-3-carboxamide

ethyl 2-methoxynicotinate

1-Methyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid ethyl ester

2-hydroxynicotinohydrazide

Refernces

• 1、 Backes, Gregory L.,Jursic, Branko S.,Neumann, Donna M.. "Potent antimicrobial agents against azole-resistant fungi based on pyridinohydrazide and hydrazomethylpyridine structural motifs". . p. 3397 - 3407. Retrieved 2015/08/03.
• 2、 Pu, Ai-Ting,Yang, Jin,Kan, Wei-Qiu,Yang, Yan,Ma, Jian-Fang. "Syntheses, structures and photoluminescent properties of a series of divalent nickel and cadmium complexes based on 3-carboxy-1-(4′-(2″- carboxy)biphenylmethyl)-2-oxidopyridinium and structurally different N-donor ligands". . p. 556 - 570. Retrieved 2013/04/10.