2-Chloro-4-methoxypyridine

Base Information

• Chemical Name: 2-Chloro-4-methoxypyridine
• CAS No.: 17228-69-2
• Molecular Formula: C6H6ClNO
• Molecular Weight: 143.573
• Hs Code.: 29333990
• European Community (EC) Number: 625-435-9
• DSSTox Substance ID: DTXSID70365830
• Nikkaji Number: J1.466.010K
• Wikidata: Q72453412
• Mol file: 17228-69-2.mol

Synonyms:2-Chloro-4-methoxypyridine;17228-69-2;2-chloro-4-methoxy-pyridine;Pyridine, 2-chloro-4-methoxy-;MFCD02093951;2-chloro-Methoxypyridine;4-methoxy-2-chloropyridine;2-chloro-4-methoxylpyridine;2-chloro-4-methoxy pyridine;SCHEMBL287199;AMY7998;DTXSID70365830;PMTPFBWHUOWTNN-UHFFFAOYSA-N;2-Chloro-4-methoxypyridine, 97%;BCP09377;CL0073;IFLAB-BB F1957-0003;AKOS002665931;AB10868;AC-6271;CS-W007914;PS-5464;SY019196;A3795;C3024;FT-0600588;EN300-67788;W-206022;F1957-0003

Chemical Property of 2-Chloro-4-methoxypyridine

Chemical Property:

• Vapor Pressure: 0.236mmHg at 25°C
• Refractive Index: n20/D 1.5400(lit.)
• Boiling Point: 213.8 °C at 760 mmHg
• PKA: 2.25±0.10(Predicted)
• Flash Point: 83.1 °C
• PSA: 22.12000
• Density: 1.21 g/cm³
• LogP: 1.74360
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Soluble in alcohol.
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 143.0137915
• Heavy Atom Count: 9
• Complexity: 89.1

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=NC=C1)Cl
• Uses: It is an active pharmaceutical ingredient. 2-Chloro-4-methoxypyridine may be used to synthesize:2-(2′,4′-difluorophenyl)-4-methoxypyridine(2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl)pyrimidin-4-yl]methanol(2-chloro-4-methoxypyridin-3-yl)bis-[2-(methylsulfanyl) pyrimidin-4-yl]methyl acetate

Technology Process of 2-Chloro-4-methoxypyridine

There total 10 articles about 2-Chloro-4-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloro-4-nitropyridine (23056-36-2) + tetrabutyl ammonium methoxide (34851-41-7) → 2-chloro-4-methoxy-pyridine (17228-69-2)

Guidance literature:

In tetrahydrofuran; methanol; at 23 ℃; for 2h;

DOI:10.1021/ol047688v

Reference yield: 81.0%

2-chloropyridin-4-ol (17368-12-6) + methyl iodide (74-88-4) → 2-chloro-4-methoxy-pyridine (17228-69-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

Reference yield: 81.0%

methanol (67-56-1) + 2-chloro-4-nitropyridine (23056-36-2) → 2-chloro-4-methoxy-pyridine (17228-69-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2004.03.001

upstream raw materials:

2-chloro-4-nitropyridine

sodium methylate

methanol

tetrabutyl ammonium methoxide

Downstream raw materials:

2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(4-methoxypyridin-2-yl)oxazole

1-(4-methoxy-pyridin-2-yl)-piperazine

2-chloro-6-cyano-4-methoxy pyridine

5-bromo-2-chloro-4-methoxypyridine

Refernces

• 1、 -. "BET INHIBITORS FOR MODULATING DUX4 EXPRESSION IN FSHD". Page/Page column 203. . Retrieved 2020/07/14.
• 2、 Mizuno, Hajime,Takaya, Jun,Iwasawa, Nobuharu. "Rhodium(I)-catalyzed direct carboxylation of arenes with CO2 via chelation-assisted C-H bond activation". supporting information; experimental part. p. 1251 - 1253. Retrieved 2011/04/16.