2-Amino-4-fluoropyridine

Base Information

• Chemical Name: 2-Amino-4-fluoropyridine
• CAS No.: 944401-77-8
• Molecular Formula: C5H5FN2
• Molecular Weight: 112.107
• Hs Code.: 2933399090
• European Community (EC) Number: 815-037-5
• DSSTox Substance ID: DTXSID20592836
• Nikkaji Number: J3.499.743H
• Wikidata: Q72437441
• Mol file: 944401-77-8.mol

Synonyms:2-Amino-4-fluoropyridine;944401-77-8;4-fluoropyridin-2-amine;MFCD09260906;4-FLUORO-2-PYRIDINAMINE;4-FLUORO-PYRIDIN-2-YLAMINE;Amino-4-fluoropyridine;4-fluoro-pyridin-2-amine;SCHEMBL310167;SCHEMBL23104502;DTXSID20592836;WCCFLOQQACDOAX-UHFFFAOYSA-N;BCP26403;BBL101541;STL555337;2-amino-4-fluoropyridine, AldrichCPR;AKOS006238128;AB50025;AC-3168;CS-W005118;HY-W005118;SY004151;TS-01558;DB-082075;AM20061637;EN300-56054;W-204107

Chemical Property of 2-Amino-4-fluoropyridine

Chemical Property:

• Vapor Pressure: 0.182mmHg at 25°C
• Melting Point: 102 °C
• Refractive Index: 1.554
• Boiling Point: 211.49 °C at 760 mmHg
• PKA: 6.42±0.11(Predicted)
• Flash Point: 81.706 °C
• PSA: 38.91000
• Density: 1.257 g/cm³
• LogP: 1.38410
• Storage Temp.: Refrigerated.
• Water Solubility.: Slightly soluble in water.
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 112.04367633
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=C1F)N
• Uses: 2-Amino-4-fluoropyridine is an important intermediate for organic synthesis and pharmaceuticals.

Technology Process of 2-Amino-4-fluoropyridine

There total 1 articles about 2-Amino-4-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-pyridine-2-carbonitrile (19235-89-3) → 4-fluoropyridin-2-amine (944401-77-8)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutylammomium bromide; potassium fluoride / N,N-dimethyl-formamide / 120 - 140 °C / Inert atmosphere

2: sodium hydroxide; dihydrogen peroxide / ethanol / 20 °C

3: sodium hydroxide; bromine / water / 0 - 80 °C

With potassium fluoride; tetrabutylammomium bromide; dihydrogen peroxide; bromine; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

Reference yield: 97.0%

4-acetoxybenzoyl chloride (27914-73-4) + 4-fluoropyridin-2-amine (944401-77-8) → 4-[(4-fluoropyridin-2-yl)carbamoyl]phenyl acetate

Guidance literature:

In pyridine; dichloromethane; at 20 ℃;

Reference yield: 87.0%

4-fluoropyridin-2-amine (944401-77-8) + dichloromethane (75-09-2) + diethylamine (109-89-7) + α-bromoacetophenone (70-11-1) → N-ethyl-N-((7-fluoro-2-phenylimidazo[1,2-a]pyridin-3-yl)methyl)ethanamine

Guidance literature:

In ethanol; at 20 ℃; for 1h; Schlenk technique; Green chemistry;

DOI:10.1039/d1gc01017d

upstream raw materials:

4-chloro-pyridine-2-carbonitrile

Downstream raw materials:

5-bromo-4-fluoro-pyridin-2-ylamine

C₂₆H₃₁FN₄O₄S

(1S,2R,3R)-2.3-dimethyl-1-(8-fluoro-1,2,3,4-tetrahydropyrido[3',4':4,5]imidazo[1,2-a]pyridine-2-sulfonylamino)-2-phenylcyclopropane-1-carboxylic acid

phosphoric acid 2-(2-azidomethyl-7-fluoroimidazo[1,2-a]pyridin-3-yl)ethyl ester diphenyl ester

Refernces