2-Amino-3-methoxypyridine

Base Information

• Chemical Name: 2-Amino-3-methoxypyridine
• CAS No.: 10201-71-5
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• Hs Code.: 2933399090
• European Community (EC) Number: 688-408-0
• DSSTox Substance ID: DTXSID70432773
• Nikkaji Number: J1.936.725H
• Wikidata: Q72438967
• Mol file: 10201-71-5.mol

Synonyms:3-methoxy-2-aminopyridine

Chemical Property of 2-Amino-3-methoxypyridine

Chemical Property:

• Vapor Pressure: 0.051mmHg at 25°C
• Refractive Index: 1.561
• Boiling Point: 234.996 °C at 760 mmHg
• PKA: 8.43±0.10(Predicted)
• Flash Point: 95.922 °C
• PSA: 48.14000
• Density: 1.14 g/cm³
• LogP: 1.25360
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(N=CC=C1)N

Technology Process of 2-Amino-3-methoxypyridine

There total 11 articles about 2-Amino-3-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-methoxy-2-nitropyridine (20265-37-6) → 3-methoxypyridin-2-amine (10201-71-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; for 3h;

Reference yield: 77.0%

2-bromo-3-methoxypyridine (24100-18-3) → 3-methoxypyridin-2-amine (10201-71-5)

Guidance literature:

With copper acetylacetonate; potassium phosphate; ammonia; In N,N-dimethyl-formamide; at 90 ℃; for 24h; chemoselective reaction; Glovebox; Autoclave;

DOI:10.1002/adsc.201201010

Reference yield: 74.0%

→ 3-methoxypyridin-2-amine (10201-71-5)

Guidance literature:

upstream raw materials:

3-methoxy-2-nitropyridine

2-amino-3-hydroxypyridine

2-bromo-3-methoxypyridine

diazomethane

Downstream raw materials:

5-bromo-3-methoxy-pyridin-2-amine

3-Iodo-N-(3-methoxypyridin-2-yl)benzamide

3,3'-{[(3-Methoxypyridin-2-yl)imino]dicarbonyl}dibenzenesulfonyl chloride

Refernces

• 1、 Huang, Haigen,Wang, Xueguang,Tan, Mingwu,Chen, Chenju,Zou, Xiujing,Ding, Weizhong,Lu, Xionggang. "Solvent-Free Selective Hydrogenation of Nitroarenes Using Nanoclusters of Palladium Supported on Nitrogen-Doped Ordered Mesoporous Carbon". . p. 1485 - 1489. Retrieved 2016.
• 2、 Ballet, Steven,Elsocht, Mathias,Hollanders, Charlie,Jida, Mouhamad,Maes, Bert U. W.,Renders, Evelien,Van der Poorten, Olivier. "3-Substituted 2-isocyanopyridines as versatile convertible isocyanides for peptidomimetic design". . p. 6863 - 6866. Retrieved 2021.