2,6-Dichloro-4-(trifluoromethyl)benzene-1-sulfonyl chloride

Base Information

• Chemical Name: 2,6-Dichloro-4-(trifluoromethyl)benzene-1-sulfonyl chloride
• CAS No.: 175205-76-2
• Molecular Formula: C7H2Cl3F3O2S
• Molecular Weight: 313.512
• Hs Code.: 2904909090
• European Community (EC) Number: 642-504-9
• DSSTox Substance ID: DTXSID20371663
• Wikidata: Q82159077
• Mol file: 175205-76-2.mol

Synonyms:175205-76-2;2,6-dichloro-4-(trifluoromethyl)benzene-1-sulfonyl chloride;2,6-dichloro-4-(trifluoromethyl)benzenesulfonyl Chloride;2,6-dichloro-4-(trifluoromethyl)benzenesulfonylchloride;2,6-dichloro-4-(trifluoromethyl)benzene sulphonyl chloride;Benzenesulfonyl chloride, 2,6-dichloro-4-(trifluoromethyl)-;C7H2Cl3F3O2S;2,6-dichloro-4-(trifluoromethyl)benzenesulphonyl chloride;2,6-dichloro-4-(trifluoromethyl)benzenesulfonyl;SCHEMBL533215;DTXSID20371663;MFCD00220929;AKOS015849905;AS-47768;CS-0205933;FT-0610575;F16076;A811954;2,6-Dichloro-4-trifluoromethylbenzenesulfonyl chloride;2,6-dichloro-4-(trifluoromethyl)benzene-1-sulfonylchloride;Benzenesulfonylchloride,2,6-dichloro-4-(trifluoromethyl)-;2,6-dichloro-4-(trifluoromethyl)benzenesulphonyl chloride, AldrichCPR

Chemical Property of 2,6-Dichloro-4-(trifluoromethyl)benzene-1-sulfonyl chloride

Chemical Property:

• Vapor Pressure: 0.177mmHg at 25°C
• Melting Point: 47 °C
• Refractive Index: 1.502
• Boiling Point: 297.536 °C at 760 mmHg
• Flash Point: 133.746 °C
• PSA: 42.52000
• Density: 1.708 g/cm³
• LogP: 5.02050
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 311.879318
• Heavy Atom Count: 16
• Complexity: 339

Purity/Quality:

99% ^*data from raw suppliers

2,6-Dichloro-4-(trifluoromethyl)benzenesulfonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C; Xi
• Hazard Codes: C,Xi
• Statements: 34-36/37/38-36
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1Cl)S(=O)(=O)Cl)Cl)C(F)(F)F

Technology Process of 2,6-Dichloro-4-(trifluoromethyl)benzene-1-sulfonyl chloride

There total 1 articles about 2,6-Dichloro-4-(trifluoromethyl)benzene-1-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2,6-dichloro-4-(trifluoromethyl)benzenesulfonyl chloride (175205-76-2)

Guidance literature:

Reference yield: 80.0%

2,6-dichloro-4-(trifluoromethyl)benzenesulfonyl chloride (175205-76-2) + methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile (10128-91-3) → C14H8Cl2F3NO5S

Guidance literature:

methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile; With sodium hydride; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

2,6-dichloro-4-(trifluoromethyl)benzenesulfonyl chloride; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.06.068

Reference yield: 76.0%

2,6-dichloro-4-(trifluoromethyl)benzenesulfonyl chloride (175205-76-2) + 6,6'-diamino-2,3,4,2',3',4'-hexa-O-benzoyl-6,6'-dideoxy-α,α-trehalose dihydrochloride → C68H50Cl4F6N2O19S2

Guidance literature:

6,6'-diamino-2,3,4,2',3',4'-hexa-O-benzoyl-6,6'-dideoxy-α,α-trehalose dihydrochloride; With sodium hydrogencarbonate; In methanol; for 0.0833333h;

2,6-dichloro-4-(trifluoromethyl)benzenesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/cmdc.202000775

Downstream raw materials:

SB 611812

1-(2,6-dichloro-4-trifluoromethyl-benzenesulfonyl)-piperidine-2-carboxylic acid ethyl ester

C₁₃H₁₂Cl₂F₃NO₄S

Refernces

• 1、 -. "Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists". . . Retrieved 2008/06/13.