Motesanib

Base Information

• Chemical Name: Motesanib
• CAS No.: 453562-69-1
• Deprecated CAS: 894356-47-9
• Molecular Formula: C22H23N5O
• Molecular Weight: 373.458
• Hs Code.: 2933399990
• UNII: U1JK633AYI
• ChEMBL ID: CHEMBL572881
• DSSTox Substance ID: DTXSID10196488
• Metabolomics Workbench ID: 57626
• NCI Thesaurus Code: C71896
• Nikkaji Number: J2.121.082J
• Pharos Ligand ID: 6GW4RHUZXBXK
• Wikidata: Q6917202
• Wikipedia: Motesanib
• Mol file: 453562-69-1.mol

Synonyms:AMG 706;AMG-706;AMG706;motesanib;motesanib diphosphate

Chemical Property of Motesanib

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.669
• Boiling Point: 517.258 °C at 760 mmHg
• PKA: 11.75±0.40(Predicted)
• Flash Point: 266.628 °C
• PSA: 78.94000
• Density: 1.251 g/cm³
• LogP: 4.32810
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 373.19026037
• Heavy Atom Count: 28
• Complexity: 533

Purity/Quality:

98%,99%, ^*data from raw suppliers

Motesanib ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
• Recent ClinicalTrials: AMG 706 and Octreotide in Treating Patients With Low-Grade Neuroendocrine Tumors
• Recent EU Clinical Trials: A Phase 3, Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial
• Recent NIPH Clinical Trials: None
• Uses: Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM/3 nM/6 nM, 84 nM, 8 nM and 59 nM, respectively. Motesanib is an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma.

Technology Process of Motesanib

There total 2 articles about Motesanib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(1-acetyl-3,3-dimethylindolin-6-yl){2-[(4-pyridylmethyl)-amino](3-pyridyl)}-carboxamide (453562-74-8) → motesanib (453562-69-1)

Guidance literature:

Reference yield:

→ motesanib (453562-69-1)

Guidance literature:

Reference yield: 8.0%

motesanib (453562-69-1) → 3,3-dimethyl-N-((2-(pyridin-4-ylmethylamino)pyridin-3-yl)methyl)indolin-6-amine (1376615-70-1)

Guidance literature:

motesanib; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃; for 49h; Inert atmosphere; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 70 ℃; for 3h;

With sodium hydroxide; In water; pH=8 - 9;

upstream raw materials:

N-(1-acetyl-3,3-dimethylindolin-6-yl){2-[(4-pyridylmethyl)-amino](3-pyridyl)}-carboxamide

Downstream raw materials:

3,3-dimethyl-N-((2-(pyridin-4-ylmethylamino)pyridin-3-yl)methyl)indolin-6-amine

Refernces

• 1、 -. "Substituted alkylamine derivatives and methods of use". Page 126. . Retrieved 2010/02/05.