Chemical Property of DANTROLENE
Edit
Chemical Property:
- PKA:pKa 7.5 (Uncertain)
- PSA：120.73000
- Density:1.57±0.1 g/cm3(Predicted)
- LogP:2.53040
- Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
- Solubility.:DMSO (Slightly), Methanol (Very Slightly, Sonicated)
- Purity/Quality:
-
95-99% *data from raw suppliers
Dantrolene United States Pharmacopeia (USP) Reference Standard *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
-
Description
Dantrolene is a drug that causes spastic muscle contraction. Unlike other muscle relaxants,
it has a direct effect on the contractile mechanism by interfering in the process of calcium
ion release from the sarcoplasmic reticulum. This results in a lack of coordination in the
mechanism of excitation––contraction of skeletal muscle, which has a greater effect on
fast muscle fibers than on slow muscle fibers.
-
Uses
Dantrolene is used for controlling the onset
of clinical spasticity resulting from serious clinical cases such as wounds, paralysis, cerebral
palsy, and disseminated sclerosis. Synonyms of this drug are dantrium and danlen.
-
Biological Functions
The site of action of dantrolene is believed to be at the sarcoplasmic reticulum in skeletal muscle
cells. Dantrolene binds to a calcium channel protein (ryanodine receptor) on the sarcoplasmic
reticulum to close the channel and inhibit the release of calcium; the alkaloid ryanodine activates
the same receptor to open the channel.
-
Clinical Use
Dantrolene is a hydantoin derivative that acts peripherally to reduce spasticity and is indicated
for use in spinal cord injury, stroke, cerebral palsy, and multiple sclerosis.
