4-AMINO-5-PHENYL-PENT-2-ENOIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-AMINO-5-PHENYL-PENT-2-ENOIC ACID METHYL ESTER
• CAS No.: 99281-72-8
• Molecular Formula: C12H15 N O2
• Molecular Weight: 205.25
• Hs Code.: 2922499990
• Mol file: 99281-72-8.mol

Synonyms:4-AMINO-5-PHENYL-PENT-2-ENOIC ACID METHYL ESTER

Chemical Property of 4-AMINO-5-PHENYL-PENT-2-ENOIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.000129mmHg at 25°C
• Boiling Point: 334.3°Cat760mmHg
• Flash Point: 183°C
• PSA: 52.32000
• Density: 1.083g/cm³
• LogP: 1.98590

Purity/Quality:

99%min ^*data from raw suppliers

4-AMINO-5-PHENYL-PENT-2-ENOIC ACID METHYL ESTER 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-5-PHENYL-PENT-2-ENOIC ACID METHYL ESTER

There total 6 articles about 4-AMINO-5-PHENYL-PENT-2-ENOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-(S)-4-tert-butoxycarbonylamino-5-phenyl-pent-2-enoic acid methyl ester (99298-05-2) → (E)-(S)-4-Amino-5-phenyl-pent-2-enoic acid methyl ester (99281-72-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja00042a052

Reference yield:

Boc-L-phenylalaninal (72155-45-4) → (E)-(S)-4-Amino-5-phenyl-pent-2-enoic acid methyl ester (99281-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: aq. HCl / dioxane

With hydrogenchloride; In 1,4-dioxane; benzene; 1: Wittig reaction;

DOI:10.1039/b414846k

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → (E)-(S)-4-Amino-5-phenyl-pent-2-enoic acid methyl ester (99281-72-8)

Guidance literature:

Multi-step reaction with 4 steps

1: DCC / CH₂Cl₂

2: LiAlH₄ / tetrahydrofuran

3: CH₂Cl₂

4: TFA / CH₂Cl₂

With lithium aluminium tetrahydride; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00042a052

upstream raw materials:

(E)-(S)-4-tert-butoxycarbonylamino-5-phenyl-pent-2-enoic acid methyl ester

Boc-L-phenylalaninal

N-tert-butoxycarbonyl-L-phenylalanine

Boc-Phe-OH N,O-dimethyl hydroxamate

Downstream raw materials:

(E)-(S)-4-{[Bis-(3-fluoro-phenyl)-methylene]-amino}-5-phenyl-pent-2-enoic acid methyl ester

(E)-(S)-4-(2-tert-Butoxycarbonylamino-acetylamino)-5-phenyl-pent-2-enoic acid methyl ester

(E)-(S)-4-((E)-(S)-4-tert-Butoxycarbonylamino-5-phenyl-pent-2-enoylamino)-5-phenyl-pent-2-enoic acid methyl ester

Refernces

• 1、 Oh, Joon Seok,Jeon, Jongho,Park, Do Yeon,Kim, Young Gyu. "Stereoselective dihydroxylation reactions of γ-amino-α,β- unsaturated esters via their aryl ketimine derivatives". . p. 770 - 771. Retrieved 2007/10/03.