Sodium diformylamide

Base Information

• Chemical Name: Sodium diformylamide
• CAS No.: 18197-26-7
• Molecular Formula: C2H3 N O2 . Na
• Molecular Weight: 95.0331
• Hs Code.: 29251900
• European Community (EC) Number: 629-644-6
• DSSTox Substance ID: DTXSID50446676
• Mol file: 18197-26-7.mol

Synonyms:Sodium diformylamide;18197-26-7;Diformylimide sodium salt;sodium;diformylazanide;Sodium Diformylazanide;Diformylamide Sodium Salt;(DIFORMYLAMINO)SODIUM;MFCD00145302;C2H2NNaO2;Diformylsodium;DTXSID50446676;QJXDSDLNUKLDBP-UHFFFAOYSA-M;AKOS006223198;AKOS025395398;AB03947;Sodium diformylamide, >=97.0% (NT);D2479;FT-0689549;EN300-73663;A812646;J-011647

Chemical Property of Sodium diformylamide

Chemical Property:

• Appearance/Colour: Slightly beige powder
• Vapor Pressure: 0.0548mmHg at 25°C
• Melting Point: 205°C
• Boiling Point: 206.8°C at 760 mmHg
• Flash Point: 78.9°C
• PSA: 37.38000
• LogP: 0.33730
• Storage Temp.: 0-10°C
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 94.99832259
• Heavy Atom Count: 6
• Complexity: 40.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

SodiumDiformamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(=O)[N-]C=O.[Na+]
• Uses: Reactant for preparation of:Functionalized condensed benzazolesα-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPBINOS inhibitor PHA-399733 via Bucherer-Bergs hydantoin synthesisAntibiotic resistance (C β-lactamase AmpC ) inhibitor analogues, with improved cell permeability propertiesBINOL- and H8-BINOL-based aryl phosphites as ligands in palladium-catalyzed asymmetric allylation and amination reactionsPrecursors of αVβ3 integrin antagonists

Technology Process of Sodium diformylamide

There total 4 articles about Sodium diformylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formamide (77287-34-4,77287-35-5,60100-09-6) → sodium diformamide (18197-26-7)

Guidance literature:

With sodium methylate; In methanol; for 1h; Ambient temperature;

DOI:10.1055/s-1990-26805

Reference yield: 97.7%

→ sodium diformamide (18197-26-7)

Guidance literature:

Reference yield: 97.0%

N-formylformamide (18197-22-3) → sodium diformamide (18197-26-7)

Guidance literature:

With sodium methylate; In tetrahydrofuran; at 0 ℃; for 6h;

DOI:10.1002/asia.200900181

upstream raw materials:

formamide

N-formylformamide

N,N-dimethyl-formamide

Downstream raw materials:

N-[2-(3,4-Dimethyl-phenyl)-2-oxo-ethyl]-formamide

C₁₂H₁₃NO₃

ω-Amino-3,4-dimethyl-acetophenon

N-(2-(2,4-dimethylphenyl)-2-oxoethyl)formamide

Refernces

• 1、 -. "Processes for the preparation of agomelatine and its intermediates". Paragraph 0121. . Retrieved 2013/03/26.
• 2、 Hartner, Frederick W.,Hsiao, Yi,Eng, Kan K.,Rivera, Nelo R.,Palucki, Michael,Tan, Lushi,Yasuda, Nobuyoshi,Hughes, David L.,Weissman, Steven,Zewge, Daniel,King, Tony,Tschaen, Dave,Volante. "Methods for the synthesis of 5,6,7,8-tetrahydro-1,8-naphthyridine fragments for αvβ3 integrin antagonists". . p. 8723 - 8730. Retrieved 2007/10/03.