4-Bromo-2-methoxybenzaldehyde

Base Information

• Chemical Name: 4-Bromo-2-methoxybenzaldehyde
• CAS No.: 43192-33-2
• Molecular Formula: C8H7BrO2
• Molecular Weight: 215.046
• Hs Code.: 29130000
• European Community (EC) Number: 627-704-6
• DSSTox Substance ID: DTXSID60453472
• Nikkaji Number: J932.708H
• Wikidata: Q72446041
• Mol file: 43192-33-2.mol

Synonyms:4-Bromo-2-methoxybenzaldehyde;43192-33-2;4-bromo-2-methoxy-benzaldehyde;2-Methoxy-4-broMobenzaldehyde;BENZALDEHYDE, 4-BROMO-2-METHOXY-;MFCD08276823;SCHEMBL11173;4-bromo-2-methoxybezaldehyde;4-bromo-2-methoxybenz-aldehyde;DTXSID60453472;YMXQYZABFWVXEK-UHFFFAOYSA-N;CL8336;4-Bromo-2-methoxybenzaldehyde, 97%;4-Bromo-2-methoxybenzenecarboxaldehyde;AKOS007930628;?4-BROMO-2-METHOXYBENZALDEHYDE;AB44855;CS-W007792;DS-1132;SB37177;AC-28696;SY015357;AM20040466;FT-0687012;EN300-126205;A826212;W-202756;Z405051014

Chemical Property of 4-Bromo-2-methoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 67-71 °C
• Refractive Index: 1.585
• Boiling Point: 288.106 °C at 760 mmHg
• Flash Point: 128.042 °C
• PSA: 26.30000
• Density: 1.522 g/cm³
• LogP: 2.27020
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Air Sensitive
• Water Solubility.: Soluble in water.
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 213.96294
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

(4-Cyano-2,5-difluorophenyl)boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)Br)C=O
• Uses: 4-Bromo-2-methoxybenzaldehyde is used in the building block, synthesis of a nonacid degradable linker for solid-phase synthesis. Building block in the synthesis of a nonacid degradable linker for solid-phase synthesis.

Technology Process of 4-Bromo-2-methoxybenzaldehyde

There total 15 articles about 4-Bromo-2-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromosalicylaldehyde (22532-62-3) + dimethyl sulfate (77-78-1) → 4-bromo-2-methoxybenzaldehyde (43192-33-2)

Guidance literature:

With potassium carbonate; In acetone; for 0.75h; Heating;

Reference yield: 94.1%

methyl 4-bromo-2-methoxybenzoate (139102-34-4) → 4-bromo-2-methoxybenzaldehyde (43192-33-2)

Guidance literature:

With 1-methyl-piperazine; sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at -8 - 0 ℃; for 1.5h; Large scale;

Reference yield: 94.0%

sodium methylate (124-41-4) + 4-bromo-2-fluorobenzaldehyde (57848-46-1) → 4-bromo-2-methoxybenzaldehyde (43192-33-2)

Guidance literature:

In methanol; at 70 ℃;

upstream raw materials:

4-amino-2-methoxybenzaldehyde

(4-bromo-2-methoxyphenyl)methanol

4-bromosalicylaldehyde

dimethyl sulfate

Downstream raw materials:

(E)-3-(4-Bromo-2-methoxy-phenyl)-1-(2-hydroxy-3,5-diiodo-phenyl)-propenone

4-(pyridine-3-yloxy)2-methoxybenzaldehyde

Refernces

• 1、 Scott, James S.,Bailey, Andrew,Buttar, David,Carbajo, Rodrigo J.,Curwen, Jon,Davey, Paul R. J.,Davies, Robert D. M.,Degorce, Sébastien L.,Donald, Craig,Gangl, Eric,Greenwood, Ryan,Groombridge, Sam D.,Johnson, Tony,Lamont, Scott,Lawson, Mandy,Lister, Andrew,Morrow, Christopher J.,Moss, Thomas A.,Pink, Jennifer H.,Polanski, Radoslaw. "Tricyclic Indazoles - A Novel Class of Selective Estrogen Receptor Degrader Antagonists". supporting information. p. 1593 - 1608. Retrieved 2019/02/14.
• 2、 -. "METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE AND THE PURIFICATION THEREOF FOR USE AS AN ACTIVE PHARMACEUTICAL INGREDIENT". Paragraph 0178-0182. . Retrieved 2018/09/16.