3-Amino-2-dimethylaminopyridine

Base Information

• Chemical Name: 3-Amino-2-dimethylaminopyridine
• CAS No.: 5028-25-1
• Molecular Formula: C₇H₁₁N₃
• Molecular Weight: 137.184
• European Community (EC) Number: 865-561-3
• ChEMBL ID: CHEMBL4546287
• DSSTox Substance ID: DTXSID701297720
• Mol file: 5028-25-1.mol

Synonyms:5028-25-1;N2,N2-Dimethyl-2,3-pyridinediamine;3-Amino-2-dimethylaminopyridine;N2,N2-Dimethylpyridine-2,3-diamine;N~2~,N~2~-dimethyl-2,3-pyridinediamine;N(2),N(2)-Dimethylpyridine-2,3-diamine hydrochloride;2-N,2-N-dimethylpyridine-2,3-diamine;SCHEMBL2216963;CHEMBL4546287;IFJCSNNYWNTFDD-UHFFFAOYSA-N;3-amino-2-(dimethylamino)pyridine;DTXSID701297720;AKOS000147851;SB54131;dimethyl-(3-amino-pyridin-2-yl)-amine;EN300-57889;AB01002577-01

Chemical Property of 3-Amino-2-dimethylaminopyridine

Chemical Property:

• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 137.095297364
• Heavy Atom Count: 10
• Complexity: 103

Purity/Quality:

98%min ^*data from raw suppliers

N2,N2-dimethyl-2,3-pyridinediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(C)C1=C(C=CC=N1)N

Technology Process of 3-Amino-2-dimethylaminopyridine

There total 6 articles about 3-Amino-2-dimethylaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,N-dimethyl-3-nitropyridin-2-amine (5028-23-9) → 3-Amino-2-dimethylaminopyridine (5028-25-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; under 2585.81 Torr;

Reference yield:

tin(II)chloride dihydrate + N,N-dimethyl-3-nitropyridin-2-amine (5028-23-9) → 3-Amino-2-dimethylaminopyridine (5028-25-1)

Guidance literature:

With sodium hydrogencarbonate; In ethanol;

Reference yield:

n-Pent-4-enyl alcohol (821-09-0) → 3-Amino-2-dimethylaminopyridine (5028-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 100 °C

2: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 2585.81 Torr

With hydrogen; sodium hydride; palladium 10% on activated carbon; In methanol; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

2-chloro-3-aminopyridine

dimethyl amine

N,N-dimethyl-3-nitropyridin-2-amine

n-Pent-4-enyl alcohol

Refernces

• 1、 -. "ANTI-CANCER AGENTS ANS USES THEREOF". Page/Page column 156. . Retrieved 2010/11/29.
• 2、 -. "Anti-cancer agents and uses thereof". Page/Page column 53. . Retrieved 2008/06/13.