(+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester

Base Information

• Chemical Name: (+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester
• CAS No.: 934371-48-9
• Molecular Formula: C₁₇H₂₄N₂O₄
• Molecular Weight: 320.389
• Mol file: 934371-48-9.mol

Synonyms:(+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester

Chemical Property of (+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester

Chemical Property:

• Melting Point: >47°C (dec.)
• Boiling Point: 518.0±60.0 °C(Predicted)
• Density: 1.22±0.1 g/cm3(Predicted)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

(S)-CarbidopaMethylEsterN-Cyclohexylidene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-Carbidopa Methyl Ester N-cyclohexylideneis an impurity of Carbidopa (C175915), a prodrug inhibitor of aromatic amino acid decarboxylase.

Technology Process of (+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester

There total 1 articles about (+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

L-methyldopa methyl ester (18181-08-3,1259578-15-8) + 1-oxa-2-azaspiro[2.5]octane (185-80-8) → (+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester (934371-48-9)

Guidance literature:

In toluene; at 5 - 105 ℃; for 1.33333h;

Reference yield: 87.0%

(+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester (934371-48-9) → S(-)-carbidopa (302-53-4,14585-65-0,28860-95-9,28875-92-5,31823-41-3)

Guidance literature:

(+)-(L)-2-(N'-cyclohexylidenehydrazino)-3-(3,4-dihydroxyphenyl)-2-methyl propionic acid methyl ester; With hydrogenchloride; In water;

With ammonia; In water; pH=3.5;

upstream raw materials:

L-methyldopa methyl ester

1-oxa-2-azaspiro[2.5]octane

Downstream raw materials:

S(-)-carbidopa

Refernces