N-BOC-2-AMINO-5-BROMOTHIAZOLE

Base Information

• Chemical Name: N-BOC-2-AMINO-5-BROMOTHIAZOLE
• CAS No.: 405939-39-1
• Molecular Formula: C8H11BrN2O2S
• Molecular Weight: 279.158
• Hs Code.: 2934100090
• Mol file: 405939-39-1.mol

Synonyms:Carbamicacid, (5-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI);(5-Bromothiazol-2-yl)carbamic acid tert-butyl ester;tert-Butyl(5-bromo-1,3-thiazol-2-yl)carbamate;tert-ButylN-(5-bromothiazol-2-yl)carbamate;

Chemical Property of N-BOC-2-AMINO-5-BROMOTHIAZOLE

Chemical Property:

• Refractive Index: 1.596
• PKA: 4.58±0.70(Predicted)
• PSA: 79.46000
• Density: 1.574 g/cm³
• LogP: 3.32560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Boc-2-amino-5-bromothiazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-2-AMINO-5-BROMOTHIAZOLE

There total 6 articles about N-BOC-2-AMINO-5-BROMOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-bromo-2-aminothiazole (3034-22-8) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-bromothiazol-2-ylcarbamate (405939-39-1)

Guidance literature:

With pyridine;

DOI:10.1016/j.bmcl.2010.07.102

Reference yield: 92.0%

di-tert-butyl dicarbonate (24424-99-5) + 5-bromothiazol-2-amine hydrobromide (61296-22-8) → tert-butyl 5-bromothiazol-2-ylcarbamate (405939-39-1)

Guidance literature:

With pyridine; at 25 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0029-1219230

Reference yield: 74.0%

tert-butyl 1,3-thiazole-2-yl-carbamate (170961-15-6) → tert-butyl 5-bromothiazol-2-ylcarbamate (405939-39-1)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1002/cmdc.202100568

upstream raw materials:

5-bromo-2-aminothiazole

di-tert-butyl dicarbonate

tert-butyl 1,3-thiazole-2-yl-carbamate

5-bromothiazol-2-amine hydrobromide

Downstream raw materials:

tert-butyl (5-bromothiazol-2-yl)(4-methoxybenzyl)carbamate

(S)-tert-butyl 1-(N-(5-bromothiazol-2-yl)-tert-butoxycarbonylamino)-3-(4-(trifluoromethyl)phenyl)propan-2-ylcarbamate

Refernces

• 1、 -. "NOVEL INHIBITOR OF CYCLIN-DEPENDENT KINASE CDK9". Paragraph 0059. . Retrieved 2020/03/13.
• 2、 -. "COMPOUNDS AND USES THEREOF". Page/Page column 355-356. . Retrieved 2019/10/15.