TGX-D₁

Base Information

• Chemical Name: TGX-D₁
• CAS No.: 1308384-65-7
• Molecular Formula: C₂₃H₂₈N₄O₃
• Molecular Weight: 408.5
• Mol file: 1308384-65-7.mol

Synonyms:TGX-D₁

Chemical Property of TGX-D₁

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TGX-D₁

There total 16 articles about TGX-D₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

C16H21N3O5S (1374310-67-4) + 2-Anilinoethanol (122-98-5) → TGX-D1 (1308384-65-7)

Guidance literature:

With triethylamine; In dichloromethane; for 15h; Reflux;

DOI:10.1021/mp3000309

Reference yield: 50.0%

C24H28N4O4 (1307864-98-7) → TGX-D1 (1308384-65-7)

Guidance literature:

With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; at 20 ℃; for 24h;

DOI:10.1021/mp200007b

Reference yield:

TGX066 (351002-16-9) → TGX-D1 (1308384-65-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine

1.2: 20 °C

2.1: toluene / 4 h / Reflux; Molecular sieve; Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 85 °C

5.1: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 24 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; ethanol; toluene; acetonitrile;

DOI:10.1021/mp200007b

upstream raw materials:

7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one

C₂₉H₃₉N₅O₄

NH₂-SL-TGX

C₂₄H₂₈N₄O₄

Downstream raw materials:

C₂₉H₃₉N₅O₄

NH₂-SL-TGX

C₃₉H₅₈N₄O₄

C₂₉H₃₈N₄O₄

Refernces

• 1、 Tai, Wanyi,Shukla, Ravi S.,Qin, Bin,Li, Benyi,Cheng, Kun. "Development of a peptide-drug conjugate for prostate cancer therapy". . p. 901 - 912. Retrieved 2012/06/15.