2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID
• CAS No.: 84906-81-0
• Molecular Formula: C₁₀H₇NO₃
• Molecular Weight: 189.17
• Mol file: 84906-81-0.mol

Synonyms:4-Carboxy-2-hydroxyquinoline

Chemical Property of 2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 3.07E-07mmHg at 25°C
• Melting Point: >300 °C
• Boiling Point: 403.6°C at 760 mmHg
• PKA: 2.69±0.10(Predicted)
• Flash Point: 197.9°C
• PSA: 70.42000
• Density: 1.480±0.06 g/cm3(Predicted)
• LogP: 1.63860
• Storage Temp.: 2-8°C

Purity/Quality:

90.0%Min ^*data from raw suppliers

2-Hydroxyquinoline-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID

There total 19 articles about 2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.3%

malonic acid (141-82-2) + indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 2-hydroxyquinoline-4-carboxylic acid (15733-89-8,84906-81-0)

Guidance literature:

With sodium acetate; acetic acid; for 6h; Reagent/catalyst; Reflux; Large scale;

Reference yield: 65.0%

1-acetyl-1H-indole-2,3-dione (574-17-4) → 2-hydroxyquinoline-4-carboxylic acid (15733-89-8,84906-81-0)

Guidance literature:

With sodium hydroxide; In water; for 0.05h; microwave irradiation;

DOI:10.1080/00397910500184719

Reference yield:

4-methylquinolin-2-ol (607-66-9,84909-43-3) → 2-hydroxyquinoline-4-carboxylic acid (15733-89-8,84906-81-0)

Guidance literature:

With potassium permanganate; for 6h; Reflux;

DOI:10.1016/j.bioorg.2019.103171

upstream raw materials:

C₆H₄NCH₂CHCCH₂

1-acetyl-1H-indole-2,3-dione

2-chloroquinoline-4-carboxylic acid

ethyl ester of 2-chlorocinchoninic acid

Downstream raw materials:

3-[4]quinolyl-3-oxo-propionic acid ethyl ester

2-chloro-quinoline-4-carboxylic acid-(2-diethylamino-ethylamide)

2-chloroquinoline-4-amine

2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid

Refernces

• 1、 Bindu,Vijayalakshmi,Manikandan. "Discovery, synthesis and molecular substantiation of N-(benzo[d]thiazol-2-yl)-2-hydroxyquinoline-4-carboxamides as anticancer agents". . . Retrieved 2019/08/07.
• 2、 -. "Anti-Malarial Agents". Paragraph 0271-0274. . Retrieved 2015/02/25.