1,3-Dichloro-6-methoxyisoquinoline

Base Information

• Chemical Name: 1,3-Dichloro-6-methoxyisoquinoline
• CAS No.: 24623-39-0
• Molecular Formula: C10H7Cl2NO
• Molecular Weight: 228.07468
• Hs Code.: 2933499090
• Mol file: 24623-39-0.mol

Synonyms:1,3-Dichloro-6-methoxyisoquinoline 98%;

Chemical Property of 1,3-Dichloro-6-methoxyisoquinoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.631
• Boiling Point: 367.203 °C at 760 mmHg
• Flash Point: 175.878 °C
• PSA: 22.12000
• Density: 1.385g/cm3
• LogP: 3.55020
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

1,3-Dichloro-6-methoxyisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Dichloro-6-methoxyisoquinoline

There total 2 articles about 1,3-Dichloro-6-methoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

1-chloro-6-methoxy-isoquinoline 2-oxide (630422-24-1) → 1,3-dichloro-6-methoxyisoquinoline (24623-39-0)

Guidance literature:

1-chloro-6-methoxy-isoquinoline 2-oxide; With trichlorophosphate; for 3h; Heating / reflux;

With sodium hydroxide; In water; at 0 ℃; pH=10;

Reference yield:

→ 1,3-dichloro-6-methoxyisoquinoline (24623-39-0)

Guidance literature:

5-Methoxy-2-oximino-indanon-(1), 1) POCl3, PCl5, Ograd, 3h, 2) HCl (Saettigung), 60grad, 4 h, 3) PCl5, 80grad, 4 h, 4) Entfernen v. POCl3, Vak., 5) 80grad (Sublim.);

Reference yield: 76.0%

1,3-dichloro-6-methoxyisoquinoline (24623-39-0) + 4-formylphenylboronic acid, (87199-17-5) → 6-methoxy-1,3-bis(4-formylphenyl)isoquinoline

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 24h; Reflux; Inert atmosphere; Alkaline conditions;

DOI:10.1080/14756366.2019.1706502

upstream raw materials:

1-chloro-6-methoxy-isoquinoline 2-oxide

Refernces

• 1、 -. "MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS". Page/Page column 88. . Retrieved 2010/11/25.