2,3-Dichloro-4-fluoroaniline

Base Information

• Chemical Name: 2,3-Dichloro-4-fluoroaniline
• CAS No.: 36556-52-2
• Molecular Formula: C6H4Cl2FN
• Molecular Weight: 180.01
• Hs Code.: 2921420090
• Mol file: 36556-52-2.mol

Synonyms:2,3-Dichloro-4-fluoroaniline 93%;2,3-Dichloro-4-fluoroaniline93%;1-Amino-2,3-dichloro-4-fluorobenzene;2,3-Dichloro-4-fluorobenzenamine

Chemical Property of 2,3-Dichloro-4-fluoroaniline

Chemical Property:

• Boiling Point: 253.3 °C at 760 mmHg
• PKA: 1.65±0.10(Predicted)
• Flash Point: 107 °C
• PSA: 26.02000
• Density: 1.502 g/cm³
• LogP: 3.29590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Dichloro-4-fluoroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Dichloro-4-fluoroaniline

There total 4 articles about 2,3-Dichloro-4-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2,3-dichloro-4-fluorophenylcarbamate (870065-86-4) → 2,3-dichloro-4-fluorophenylamine (36556-52-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃;

DOI:10.1021/jm051202e

Reference yield:

3-chloro-4-fluorobenzoic acid (403-16-7) → 2,3-dichloro-4-fluorophenylamine (36556-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: s-BuLi; TMEDA / tetrahydrofuran / -78 °C

1.2: Cl₃CCCl₃

2.1: triethylamine; diphenylphosphorylazide / Heating

3.1: HCl / diethyl ether / 20 °C

With hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; diphenylphosphoranyl azide; sec.-butyllithium; triethylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm051202e

Reference yield:

2,3-Dichloro-4-fluoro-benzoic acid (154257-76-8) → 2,3-dichloro-4-fluorophenylamine (36556-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; diphenylphosphorylazide / Heating

2: HCl / diethyl ether / 20 °C

With hydrogenchloride; diphenylphosphoranyl azide; triethylamine; In diethyl ether;

DOI:10.1021/jm051202e

upstream raw materials:

tert-butyl 2,3-dichloro-4-fluorophenylcarbamate

3-chloro-4-fluorobenzoic acid

2,3-Dichloro-4-fluoro-benzoic acid

Downstream raw materials:

5-tert-butyl-2-(3-(2,3-dichloro-4-fluorophenyl)ureido)thiophene-3-carboxylic acid

2,3-dichloro-1-fluoro-4-isocyanato-benzene

N-(2,3-dichloro-4-fluorophenyl)-2-pyridin-3-ylthioacetamide

N-(2,3-dichloro-4-fluorophenyl)-2-pyridin-3-ylacetamide

Refernces