2-Bromopyrazine

Base Information

• Chemical Name: 2-Bromopyrazine
• CAS No.: 56423-63-3
• Molecular Formula: C4H3BrN2
• Molecular Weight: 158.985
• Hs Code.: 2933990090
• Mol file: 56423-63-3.mol

Synonyms:Pyrazine,bromo- (9CI);2-Bromopyrazine;Bromopyrazine;

Chemical Property of 2-Bromopyrazine

Chemical Property:

• Vapor Pressure: 1.08mmHg at 25°C
• Refractive Index: 1.568
• Boiling Point: 183 °C at 760 mmHg
• PKA: -1.15±0.10(Predicted)
• Flash Point: 64.5 °C
• PSA: 25.78000
• Density: 1.726 g/cm³
• LogP: 1.23910
• Storage Temp.: ?20°C

Purity/Quality:

99% ^*data from raw suppliers

2-Bromopyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41-37/38
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromopyrazine

There total 8 articles about 2-Bromopyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(2-pyrazinyl)tributyltin → 2-bromopyrazine (56423-63-3)

Guidance literature:

With bromine; In tetrachloromethane; dichloromethane; for 0.333333h;

DOI:10.1021/ol0200091

Reference yield: 55.0%

pyrazin-2-ol (6270-63-9) → 2-bromopyrazine (56423-63-3)

Guidance literature:

With phosphorus tribromide; phosphorus(V) oxybromide; 60 deg C to 50 deg C;

Reference yield: 51.0%

2-chloropyrazin (14508-49-7) → 2-bromopyrazine (56423-63-3)

Guidance literature:

With trimethylsilyl bromide; for 72h; Reflux;

DOI:10.1002/jhet.3479

upstream raw materials:

pyrazin-2(1H)-one

pyrazine hydrochloride

pyrazin-2-ol

1,4-pyrazine

Downstream raw materials:

2,3-dibromopyrazine

2,6-dibromopyrazine

2-5-dibromopyrazine

(S)-3-(4-chlorophenyl)-4-(3-(pyrazin-2-yloxy)phenyl)oxazolidin-2-one

Refernces

• 1、 -. "CONDENSED-CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE CONDENSED-CYCLIC COMPOUND". Page/Page column. . Retrieved 2014/04/03.
• 2、 -. "SUBSTITUTED ARYLPYRAZINES". . . Retrieved 2008/06/13.